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ANGPT2 — TLR4

Text-mined interactions from Literome

Ji et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2008 : Ang II increased mRNA and protein expressions of TLR4 in RAW264.7 cells in concentration dependent manner ( P < 0.01 ), and LPS also induced mRNA and protein expressions of TLR4 in RAW264.7 cells ( P < 0.01 )
Wu et al., Inflamm Res 2009 : Ang II upregulates the expression of TLR4 by RPMCs, resulting in enhanced NF-kappaB signaling and induction of CD40, TNF-alpha, and IL-6 expression
Ji et al., Nan Fang Yi Ke Da Xue Xue Bao 2009 : Rosiglitazone downregulates Ang II-induced TLR4 expression in RAW264.7 cells and inhibits MPO secretion possibly by interfering with TLR4 to relieve the inflammatory reaction, which may be one of its anti-atherosclerotic mechanisms
Shyu et al., J Biomed Sci 2010 : TNF-alpha and Ang II significantly increased TLR4 protein expression