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Lara et al., Arch Biochem Biophys 2010
:
Cholera toxin, an activator of Gs protein, mimicked it ; ( 2 ) in the presence of Ang II , Ang- ( 1-7 ) increased the PKA activity 10-fold ; ( 3 ) the peptide inhibitor of PKA blocked the Ang- ( 1-7 ) effect on Ang II-stimulated Na+-ATPase ; ( 4 ) Ang- ( 1-7 ) reverses the Ang II-stimulated PKC activity ; ( 5 ) cAMP mimicked the Ang- ( 1-7 ) effect on the Ang II-stimulated Na+-ATPase
Ketsawatsomkron et al., Vascul Pharmacol 2010
(Insulin Resistance) :
Finally, we also showed that Ang II-induced activation of PTP-1B in VSMC was PKA/JAK2 dependent