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IRF6 — LPL

Text-mined interactions from Literome

Tengku-Muhammad et al., Cytokine 1999 : The regulation of macrophage lipoprotein lipase (LPL) by cytokines and lipopolysaccharide (LPS) is of potentially crucial importance in the pathogenesis of atherosclerosis and in the responses to endotoxin challenge ... We show here that the reduction of LPL activity in J774.2 macrophages observed in the presence of interleukin ( IL-1 ) and IL-11 was sensitive to herbimycin A, with the effect of LPS , interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) on LPL activity being sensitive to both herbimycin A and wortmannin
Hauton et al., Cell Physiol Biochem 2002 : LPS increased LPL activity 5-fold in oleate perfused spleens, but had no effect on VLDL perfused spleens
Casanovas et al., Free Radic Biol Med 2009 (Endotoxemia...) : Nitric oxide ( NO ) has been implicated in LPS induced down-regulation of LPL activity, but whether its effects are direct or indirect remains unclear
White et al., J Lipid Res 1988 (Arteriosclerosis) : The effect of LPS on macrophage LPL activity was rapid, was blocked by polymixin B, and was not due to cytotoxicity
Sopher et al., Immunol Lett 1987 : Since the regulation of LPL secretion in macrophages is rather poorly understood, we investigated the effect of the macrophage activator LPS on LPL secretion by macrophages ... LPS did not inhibit the enzymic activity of LPL when added directly to the cell free enzyme assay system ... Thus LPS regulates macrophage secretion of LPL in a mechanism independent of the induction of autocrine production of TNF and IL-1, and possesses a disparate pattern of regulation to that expressed by adipose tissue cells
Ahrné et al., J Dairy Res 1985 : Cysteine could eliminate the effect of LPS on LPL
Nonogaki et al., Endocrinology 1994 (Hypertriglyceridemia) : alpha 1-Adrenergic receptors are involved in mediating the increased hepatic triglyceride secretion induced by low dose LPS, whereas alpha 2-adrenergic receptors are involved in mediating the decrease in lipoprotein lipase activity induced by high dose LPS