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Nick et al., J Clin Invest 1999 : LPS stimulation selectively activated p38alpha
Kraatz et al., J Surg Res 1999 : LPS pretreatment significantly inhibited MAPK, SAPK, and p38 activation by LPS stimulation ... LPS pretreatment induced tolerance decreased LPS stimulated MAP, SAP, and p38 kinase activation
Arbabi et al., J Immunol 1999 : Western blot analysis, using a dual phospho-specific p38 mitogen activated protein kinase Ab, demonstrated that EtOH pretreatment inhibited LPS induced p38 activation
van der Bruggen et al., Infect Immun 1999 : LPS induced p38 activation also was prevented by Ro 09-2210
Hashimoto et al., J Pharmacol Exp Ther 2000 : The results showed that LPS induced p38 MAP kinase phosphorylation and activity, and SB 203580 as a selective inhibitor of p38 MAP kinase activity inhibited p38 MAP kinase activity and IL-8 expression in LPS stimulated pulmonary vascular endothelial cells
Lee et al., Cancer Lett 2000 : Treatment of RAW 264.7 with IQ inhibited LPS stimulated p38 kinase phosphorylation in a dose related manner
Jeon et al., J Pharmacol Exp Ther 2000 (MAP Kinase Signaling System) : Treatment of RAW 264.7 with radicicol inhibited LPS stimulated p38 kinase phosphorylation in a dose related manner
Arbabi et al., Surgery 2000 : HTS and LPS induced prompt activation of both p38 and ERKs that peaked at 30 minutes
Kim et al., Brain Res 2000 (Glioma) : LPS transiently increased the phosphorylation of p38-MAPK and CREB
Lohrer et al., Endocrinology 2000 : LPS increased phospoinositol turnover in TtT/GF cells and induced phosphorylation of p38alpha mitogen activated protein kinase and the inhibitor ( IkappaB ) of nuclear factor-kappa B. Nuclear factor-kappa B was activated by LPS in TtT/GF cells
Ferlito et al., Shock 2001 (MAP Kinase Signaling System) : Pretreatment with pertussis toxin, which inactivates inhibitor G protein ( G alpha i ) function, significantly inhibited LPS induced p38 phosphorylation, but not LPS induced IkappaB alpha degradation
Morin et al., Am J Physiol Gastrointest Liver Physiol 2001 : Neonatal ( 4 days postnatal ) and adolescent ( 15 days postnatal ) rats were injected with LPS ( 5 microg/g ip ), a selective p38 inhibitor ( SB 203580 ), or both
Chen et al., Br J Pharmacol 2001 : In vitro kinase assays revealed that LPS and UTP induced extracellular signal regulated protein kinase ( ERK ) and p38 mitogen activated protein kinase activation were respectively inhibited by PD098059 and SB 203580
Haddad et al., Biochem Pharmacol 2002 : Whereas NAC blocked the phosphorylation/activation of MAPK ( p38 ), BSO amplified the LPS mediated effect on MAPK ( p38 )
Darveau et al., Infect Immun 2002 : It was found that p38 MAP kinase activation occurred in response to P. gingivalis LPS in human monocytes
Lo et al., Carcinogenesis 2002 : Carnosol also inhibited LPS induced p38 and p44/42 mitogen activated protein kinase ( MAPK ) activation at a higher concentration ( 20 microM )
Yan et al., Infect Immun 2002 : LPS mediated activation of p38 in human PMNs was dependent on the presence of LPS binding protein from plasma and CD14 on the surfaces of the cells
Xagorari et al., Br J Pharmacol 2002 : Pretreatment of RAW 264.7 with luteolin inhibited the LPS induced ERK1/2 and p38 , but not JNK1/2, phosphorylation, and blocked the LPS induced TNF-alpha release
Schilling et al., Infect Immun 2003 : The LPS receptor complex utilized by the bladder epithelial cell lines included CD14 and Toll-like receptors, and signaling involved the activation of NF-kappaB and p38 mitogen activated protein kinase
Raychaudhuri et al., Am J Respir Cell Mol Biol 2004 : Survanta also inhibited extracellular signal regulated kinase and p38 MAP kinase activity induced by LPS
Chen et al., J Cell Physiol 2003 : LPS caused a biphasic activation of p42/44 MAPKs, an early increase peaking at 30 min and a second sustained phase, lasting up to 24 h ; LPS also caused an early and sustained increase p38 MAPK activity
Khadaroo et al., Surgery 2003 : H ( 2 ) O ( 2 ) augmented the LPS induced p38 phosphorylation ... Oxidants seem to alter the LPS induced activation of p38
Boehmer et al., J Leukoc Biol 2004 (Inflammation) : We conclude that macrophages from aged mice exhibited suppressed proinflammatory cytokine production, which correlated with diminished total levels and LPS stimulated activation of p38 and JNK
Huang et al., Nat Immunol 2004 : Furthermore, MEKK3 is crucial for IL-1- and LPS induced activation of NF-kappaB and JNK-p38 but not ERK, indicating that MAPKs are differentially activated during IL-1R-TLR4 signaling
Kim et al., Experimental biology and medicine (Maywood, N.J.) 2004 : Se specifically blocked the LPS induced activation of p38 but not that of c-jun-N-terminal kinase and extracellular signal regulated kinase ; the p38-specific pathway was confirmed using p38 inhibitor SB 203580
Huang et al., Mol Pharmacol 2004 : LPS activated p38 mitogen activated protein kinase ( MAPK ), whereas IFNgamma activated Janus kinase and signal transducer and activator of transcription-1 ( STAT1 )
Jinnouchi et al., J Leukoc Biol 2005 (MAP Kinase Signaling System) : Inhibition of priming by local anesthetics was reversed by washing and incubating for 5 min. Tetracaine alone, but not the other local anesthetics, inhibited LPS activation of p38 mitogen activated protein kinase ( MAPK ) and MAPK kinase 3 ( kinases in the LPS signaling pathway )
Thakur et al., J Leukoc Biol 2006 : LPS stimulated extracellular signal regulated kinase ( ERK ) 1/2 and p38 phosphorylation, two signaling pathways regulated by ROS, were increased twofold in Kupffer cells from ethanol fed rats compared with pair fed controls
Inoue et al., Proc Natl Acad Sci U S A 2006 (Arthritis, Experimental) : In contrast, IL-1beta or LPS stimulated p38 phosphorylation and IL-6 production by MKK3 ( -/- ) synoviocytes were normal
Zhu et al., Int Immunol 2006 (MAP Kinase Signaling System) : Likewise, p38 mitogen activated protein kinase was activated by LPS with identical kinetics in both pMphi and sMphi
Gutiérrez-Venegas et al., Eur J Pharmacol 2006 : Luteolin pretreatment attenuated LPS induced extracellular signal regulated kinase, p38 , and Akt phosphorylation
Kim et al., Biochem Biophys Res Commun 2006 (Glioma) : C6 matrices inhibited LPS mediated activation of p38 and JNK MAP kinases
Patil et al., Oral Microbiol Immunol 2006 (MAP Kinase Signaling System) : The contribution of p38 MAPK LPS induced IL-6 expression was confirmed using MKK-3/6 dominant negative stable mPDL cell lines
Jin et al., J Cell Biochem 2007 (Muscular Atrophy) : LPS activated p38 and NF-kappaB, while inhibiting AKT ; whereas, curcumin administration inhibited LPS stimulated p38 activation, without altering the effect of LPS on NF-kappaB and AKT
Bolon et al., J Cell Physiol 2007 : LPS also activated JNK1/2, p38 and ERK1/2 MAP kinases
Lin et al., Biochem Pharmacol 2007 : CYL-4d had no effect on the LPS induced phosphorylation of extracellular signal regulated kinase ( ERK ), p38 mitogen activated protein kinase ( MAPK ) and its upstream activator MAPK kinase ( MEK) 3, whereas it significantly attenuated the phosphorylation of c-Jun, c-Jun NH ( 2 ) -terminal kinase ( JNK ) and its upstream activator MEK4 in a parallel concentration dependent manner
West et al., J Trauma 2007 (Systemic Inflammatory Response Syndrome) : No basal Mono or PMN p38 was seen in healthy controls, but LPS significantly activated p38 in both cell types
Wang et al., Nutrition 2007 : The omega-3 PUFAs significantly inhibited LPS induced p38 phosphorylation
Shin et al., Arch Pharm Res 2007 (MAP Kinase Signaling System) : LPS activated both p38 and JNK in astrocytes
Yoo et al., Neurochem Int 2008 (Encephalitis...) : LPS+IFN-gamma induced p38 MAPK activation and ONOO ( - ) generation were attenuated by SB203580 or SKF-86002, specific inhibitors of p38 MAPK
Kim et al., J Microbiol Biotechnol 2008 (MAP Kinase Signaling System) : The synergistic effect of PGA1 on LPS induced IL-10 mRNA and protein production was inhibited by p38 inhibitor PD169316, and PGA1 increased LPS induced p38 phosphorylation
Lv et al., Shock 2009 (Endotoxemia...) : In vitro, LPS increases the migration of c-Rel/p65 into the nucleus and the phosphorylation of p38 and JNK, all of which are essential for LPS induced TF expression
Pan et al., Mol Nutr Food Res 2008 : We found that 6-shogaol also inhibited LPS induced activation of PI3K/Akt and extracellular signal regulated kinase 1/2, but not p38 mitogen activated protein kinase ( MAPK )
Russell et al., Mol Cell Biochem 2009 : The link between PKR activation and ROS production was mediated through p38 mitogen activated protein kinase ( MAPK ), which was activated by LPS in myotubes transfected with wild-type PKR, but not PKRDelta6
Jung et al., J Agric Food Chem 2009 : Moreover, dieckol significantly reduced LPS induced nuclear factor ?B ( NF-?B ) and p38 mitogen activated protein kinases ( MAPKs ) activation, as well as reactive oxygen species ( ROS ) production
Abe et al., Clin Exp Immunol 2009 : In comparison with LPS stimulation, LPS-ICs stimulation enhanced p38 MAPK phosphorylation significantly, which was associated with an increase in IL-12 p40 monomer/homodimer secretion
Lacour et al., J Immunotoxicol 2009 : Moreover, we found that p38MAPK , JNK, and ERK were activated by APAP or LPS alone or in association
Feng et al., Atherosclerosis 2010 : In addition, LPS induced the phosphorylation of p38MAPK and translocation of NF-kappaB p65, contributing to the up-regulated expression of Fcamr in macrophages as treatment with specific inhibitor for p38MAPK ( SB203580 ) or NF-kappaB ( PDTC ) attenuated the up-regulation of Fcalpha/mu receptor expression induced by LPS in macrophages
Kuo et al., Mol Nutr Food Res 2009 : Inotilone also inhibited LPS induced activation of PI3K/Akt and extracellular signal regulated kinase 1/2 and p38 mitogen activated protein kinase
Gonzalo et al., Neurogastroenterol Motil 2010 (Endotoxemia) : LPS increased phospho-p38 expression and the levels of carbonyls and MDA+4-HDA
Lee et al., J Med Food 2010 (MAP Kinase Signaling System) : HAK suppressed LPS induced c-Jun NH ( 2 ) -terminal kinase, p38 , and p44/p42 MAPK activation
Lu et al., Journal of neuroinflammation 2010 (Inflammation) : Resveratrol had no effect on LPS stimulated phosphorylation of ERK1/2 and p38 in microglia and astrocytes, but slightly inhibited LPS stimulated phosphorylation of JNK in astrocytes
Liao et al., J Agric Food Chem 2010 : Furthermore, the phosphorylation of p38 , JNK1/2, PKC-a and PKC-e induced by LPS was inhibited by osthole ; however, the phosphorylation of ERK1/2 and PKC-d was not reduced by osthole
Al-Mutairi et al., PLoS Pathog 2010 (Leishmaniasis, Cutaneous) : LPS induced JNK and p38 MAP kinase phosphorylation was significantly increased and prolonged in MKP-2 ( -/- ) macrophages whilst ERK phosphorylation was unaffected
Seit-Nebi et al., Cell Mol Immunol 2012 (MAP Kinase Signaling System) : Rather, MLK4 appears to be able to inhibit lipopolysaccharide (LPS) induced activation of the JNK or ERK pathways, but does not have effect on LPS induced p38 or NF-?B activation
Liang et al., J Biol Chem 2011 : It suppressed LPS induced cytokine secretion from macrophages and diminished phosphorylation of Erk1/2, p38a , I?Ba, and JNK in these cells
Mou et al., Transplant Proc 2011 : We also noted that TGF-ß1 suppressed LPS induced activation of nuclear factor ( NF ) -?B, extracellular signal related kinases ( ERK ) -1/2, and p38 in DCs
O'Dea et al., Am J Physiol Lung Cell Mol Physiol 2011 (Acute Lung Injury...) : LPS induced p38/MK2 phosphorylation was higher in lung marginated Gr-1 ( high ) than Gr-1 ( low ) monocytes and neutrophils, mirroring TNF expression
Zhang et al., J Immunol 2012 (MAP Kinase Signaling System) : We observed that two forms of the vitamin D, 1,25 ( OH ) ( 2 ) D ( 3 ), and 25 ( OH ) D ( 3 ), dose dependently inhibited LPS induced p38 phosphorylation at physiologic concentrations, IL-6 and TNF-a production by human monocytes
Kim et al., PloS one 2012 (Encephalitis) : LPS induced phosphorylation of p38 mitogen activated protein kinase and stimulation of NF-?B-responsive luciferase reporter activity was also decreased in Lrrk2-KD cells
de Jong et al., PloS one 2012 (Inflammation) : LPS induced p38 mitogen activated protein kinase ( MAPK ) and nuclear factor ( NF ) -?B activation by patient plasma was assessed by Western blotting
Mekhora et al., Asian Pac J Cancer Prev 2012 (Inflammation) : These effects were due to inhibition of LPS induced phosphorylation of JNK and p38 as well as I?B
Hsu et al., Planta Med 2012 (MAP Kinase Signaling System) : It was also found that 2 suppressed LPS induced phosphorylation of JNK and p38 mitogen activated protein kinase ( MAPK ) signaling
Bang et al., J Ethnopharmacol 2012 (MAP Kinase Signaling System) : Furthermore, AJ suppressed LPS induced NF-?B activation, degradation of I?B-a, phosphorylation of extracellular signal regulated kinase ( ERK ), c-Jun N-terminal kinase (JNK) and p38
Leow-Dyke et al., Journal of neuroinflammation 2012 (Immune System Diseases...) : In contrast, in neuronal cultures, LPS activated JNK but not ERK1/2 or p38 , and the specific JNK inhibitor SP600125 significantly blocked LPS induced KC expression and release
Tang et al., Oncol Res 2012 (Colonic Neoplasms) : LPS increased phosphorylation of ERK1/2 and p38 and activated NF-kappaB
Hong et al., BMC complementary and alternative medicine 2012 (Inflammation) : CWE blocked the LPS induced degradation of I?Ba as well as the activation of JNK, p38 and ERK1/2
Ren et al., Zhonghua Gan Zang Bing Za Zhi 2012 : In addition, the phosphorylation levels of ERK and JNK were induced in macrophages at 15 min after LPS stimulation, while the phosphorylation level of p38 MAPK was induced at 1 h ; SB216763 pretreatment suppressed the LPS stimulated ERK, JNK and p38 phosphorylation in macrophages
Khan et al., J Ethnopharmacol 2013 (Edema...) : The LPS induced activation of p-JNK, p-p38 , p-ERK, and p-Akt was significantly inhibited
Reece et al., Immunology 2013 : We show for the first time that LPS stimulation of CB progenitor cells results in autocrine activation of p38 MAPK dependent GM-CSF secretion facilitating Eo/B differentiation ex vivo
Sanghera et al., J Immunol 1996 : Bacterial LPS stimulation of murine macrophages leads to increased tyrosine phosphorylation and activation of the 42- and 44-kDa mitogen activated protein kinases ( MAPK ) and the activation of stress activated protein kinases ( SAPK ) /c-Jun N-terminal kinase (JNK) and p38 , related to the high osmolarity glycerol protein kinase in Saccharomyces cerevisiae ( HOG1 )
Detmers et al., J Immunol 1998 : The time course for tyrosine phosphorylation of p38 in PMN in response to 10 ng/ml LPS in 1 % normal human serum was consistent with participation in signaling for leukocyte integrin dependent adhesion, with transient phosphorylation peaking at 10 to 20 min