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HGF — SERPINE1

Text-mined interactions from Literome

Wojta et al., Lab Invest 1999 : Therefore, we propose a role for HGF/SF in wound repair in the skin : HGF/SF -- produced by activated fibroblasts -- increases in keratinocytes the expression of PAI-1 , which leads to increased matrix stability during the repair process and which could also limit activation of HGF/SF by proteases such as urokinase-type PA ( u-PA ) or tissue-type PA ( t-PA )
Tacchini et al., Exp Cell Res 2003 (Neoplasms) : The following findings support this conclusion : ( 1 ) HGF enhanced the activity of a luciferase reporter construct under the control of multiple HIF-1 responsive elements (HRE) in HepG2 cells, and the cotransfection of the dominant negative for the beta-subunit ( ARNT ) prevented this increase ; ( 2 ) HGF activated uPA and PAI-1 promoters through HIF-1 activity regulated by PI3K/JNK1 transducers, as demonstrated by cotransfection with the reporter gene promoters and the dominant negative for ARNT, p85 subunit of PI3K or JNK1 ; ( 3 ) hypoxia was additive to HGF in increasing reporter vector activities, but probably through different transduction pathways ; ( 4 ) JNK1 wild-type expression vector increased HIF-1alpha protein expression probably in a phosphorylated state and, thus, functional for transactivating activity ; and ( 5 ) c-Jun did not seem to be involved in the activation of the luciferase construct containing multiple HREs because it was not prevented by expression of TAM-67, which is the dominant negative mutant form for c-Jun
Wang et al., Hepatology 2005 (Cholestasis...) : Furthermore, PAI-1-/- mice had higher levels of tPA activation and mature hepatocyte growth factor (HGF) after BDL than WT mice, suggesting that PAI-1 effects on HGF activation critically influence cholestatic liver injury
Imagawa et al., Arterioscler Thromb Vasc Biol 2006 (MAP Kinase Signaling System) : HGF increased PAI-1 mRNA expression and PAI-1 protein accumulation in the conditioned media of human liver derived HepG2 cells, and increased hepatic PAI-1 mRNA expression in vivo in mice ... Because USFs are involved in the regulation of carbohydrates and lipid metabolism, HGF mediated PAI-1 production may provide a novel link between atherothrombosis and metabolic derangements
Wojta et al., Blood 1994 (Carcinoma, Hepatocellular...) : Because u-PA has been shown to activate latent HGF to the active form, it could furthermore be speculated that by upregulating PAI-1 , which in turn could inhibit u-PA, HGF might regulate its own activation