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FADD — NFKB1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Chaudhary et al., Oncogene 2000
:
Dominant negative mutants of the Caspase 8 prodomain can block
NF-kappaB induced by Caspase 8,
FADD and several death receptors belonging to the TNFR family
Bannerman et al., J Clin Invest 2002
:
The
Fas associated death domain protein suppresses activation of
NF-kappa B by LPS and IL-1 beta ... Although FADD has been classically described as a proapoptotic signaling molecule, several reports have implicated a
role for
FADD in mediating
NF-kappa B activation ... In the present report, we investigated whether
FADD could
mediate LPS activation of
NF-kappa B ... Overexpression of FADD blocked LPS induced NF-kappa B activation, whereas absence of
FADD enhanced activation of
NF-kappa B by LPS ... Together, these data indicate that
FADD negatively
regulates LPS- and IL-1 beta induced
NF-kappa B activation and that this regulation occurs upstream of I kappa B degradation
Chao et al., Am J Physiol Heart Circ Physiol 2005
:
Fas associated death-domain protein inhibits TNF-alpha mediated
NF-kappaB activation in cardiomyocytes ... Although FADD has previously been reported to play an important role in CM apoptosis, the
effect of
FADD on CM
NF-kappaB signaling, which is a proinflammatory pathway, has not been delineated ... To investigate the
role of
FADD in CM
NF-kappaB activation, we utilized adenoviral gene transfer of wild-type FADD and a truncation mutant that lacks the death-effector domain ( FADD-DED ) in rat CMs in vitro TNF-alpha activated NF-kappaB in CMs as demonstrated by phosphorylation and degradation of inhibitory-kappaB (IkappaB)-alpha enhanced nuclear p65 and NF-kappaB DNA binding activity as well as increased mRNA for the NF-kappaB dependent adhesion molecule VCAM-1 ( 19 +/- 4.1-fold ) as measured by quantitative RT-PCR ... Interestingly,
FADD-DED exhibited a similar but weaker inhibitory
effect on
NF-kappaB activation ... The
effects of
FADD on
NF-kappaB were cell-type specific ...
FADD expression also
inhibited TNF-alpha mediated
NF-kappaB activation in human endothelial cells but not in rat pulmonary artery smooth muscle cells ... In contrast,
FADD expression actually
activated NF-kappaB in human embryonic kidney (HEK)-293 cells ... In CMs,
FADD inhibited
NF-kappaB activation as well as phosphorylation of IkappaB-alpha and IkappaB kinase (IKK)-beta in response to cytokine stimulation or expression of the upstream kinases NF-kappaB inducing kinase and IKK-beta ... These data demonstrate that
FADD inhibits
NF-kappaB activation in CMs, and this inhibition likely occurs at the level of phosphorylation and activation of IKK-beta
Chen et al., Proc Natl Acad Sci U S A 2005
(Adenocarcinoma...) :
Phosphorylated
FADD induces
NF-kappaB , perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas
Arechiga et al., J Immunol 2005
:
Cutting edge :
FADD is not
required for antigen receptor mediated
NF-kappaB activation ... Thus,
FADD does not
play an essential role in
NF-kappaB activation, suggesting an alternative route by which this adaptor promotes the clonal expansion of T cells
Chaudhary et al., Immunity 1997
:
However, contrary to the previous reports, both DR4- and DR5 induced apoptosis can be blocked by dominant negative
FADD , and both receptors can
activate NF-kappaB using a TRADD dependent pathway