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EPHB2 — MAPKAPK5

Text-mined interactions from Literome

Schumacher et al., EMBO J 2004 : Expression of ERK3 in mammalian cells leads to nuclear-cytoplasmic translocation and activation of MK5 and to phosphorylation of both ERK3 and MK5 ... Remarkably, activation of MK5 is independent of ERK3 enzymatic activity, but depends on its own catalytic activity as well as on a region in the C-terminal extension of ERK3
Seternes et al., EMBO J 2004 : Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway ... Binding results in nuclear exclusion of both ERK3 and MK5 and is accompanied by ERK3 dependent phosphorylation and activation of MK5 in vitro and in vivo
Aberg et al., J Biol Chem 2006 : We conclude that MK5 activation is dependent on both ERK3 and ERK4 in these cells and that these atypical MAPKs are both physiological regulators of MK5 activity
Kant et al., J Biol Chem 2006 : Interaction of ERK4 with MK5 leads to translocation of MK5 to the cytoplasm and to its activation by phosphorylation ... In transfected HEK293 cells, where overexpressed catalytically dead ERK3 is able to activate MK5, catalytic activity of ERK4 is necessary for activation of MK5 , indicating that ERK4 directly phosphorylates MK5 ... Hence, ERK3 and ERK4 cooperate in activation of MK5
Déléris et al., J Cell Physiol 2008 : Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5 ... Importantly, we found that activation loop phosphorylation of ERK3 and ERK4 stimulates their intrinsic catalytic activity and is required for the formation of stable active complexes with MK5 and, consequently, for efficient cytoplasmic redistribution of ERK3/ERK4-MK5 complexes
Dingar et al., Cell Signal 2010 (Cardiomegaly...) : Whereas MK2 and MK3 are activated by p38 MAPK, MK5 has also been shown to be activated by ERK3 and ERK4
Shiryaev et al., Journal of molecular signaling 2011 : The MAPKAPKs MK2, MK3 and MK5 are closely related, but MK2 and MK3 are the major downstream targets of the p38MAPK pathway, while MK5 can be activated by the atypical MAPK ERK3 and ERK4, protein kinase A (PKA), and maybe p38MAPK