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CD4 — LEP

Text-mined interactions from Literome

Martín-Romero et al., Cell Immunol 2000 (Obesity) : These results demonstrate the presence of the leptin receptor in human circulating CD4 ( + ) and CD8 ( + ) T lymphocytes and a functional role of leptin as a modulator ( enhancer ) of lymphocyte stimulation with a shift toward Th1 cytokine production profile
Liu et al., J Immunol 2012 (Genetic Predisposition to Disease...) : Leptin also inhibits CD4 ( + ) CD25 ( + ) Foxp3 ( + ) regulatory T cells, which are known to contribute significantly to the mechanisms of peripheral immune tolerance