UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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CASP3 — HCLS1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: HCLS1 — CASP3 (direct interaction, enzymatic study) Ruzzene et al., Biochem J 2002 *
IRef Biogrid Interaction: HCLS1 — CASP3 (direct interaction, enzymatic study) Chen et al., Biochem Biophys Res Commun 2001 *
IRef Hprd Interaction: HCLS1 — CASP3 (in vitro) Chen et al., Biochem Biophys Res Commun 2001 *, Ruzzene et al., Biochem J 2002 *
IRef Ophid Interaction: CASP3 — HCLS1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Calderone et al., J Neurosci 2004 (Brain Ischemia) : Early CaEDTA also blocked mitochondrial release of cytochrome c and Smac/DIABLO ( second mitochondria derived activator of caspases/direct inhibitor of apoptosis protein binding protein with low pI ), caspase-3 activity ( but not procaspase-3 cleavage ), p75NTR induction , and DNA fragmentation
Mediavilla-Varela et al., Molecular cancer 2009 (Prostatic Neoplasms) : Docetaxel induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75