Gene interactions and pathways from curated databases and text-mining

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ADM — NOS1

Text-mined interactions from Literome

Li et al., Peptides 2003 : ADM stimulated nitrite production and NOS activity of the aortas, which was inhibited by PAMP, ADT or PAMP plus ADT
Dong et al., Beijing Da Xue Xue Bao 2003 : Nitrite productions and NOS activities of the aortic tissues were significantly increased by ADM in a concentration dependent manner
Yen et al., J Biomed Sci 2011 : Interestingly, biochemical evidence further showed that ADM induced increase of nNOS phosphorylation was prevented by co-microinjection with Rp-8-Br-cAMP, a PKA inhibitor
Yoshimoto et al., Br J Pharmacol 1998 : 8. These results suggest that in the rat aorta, adrenomedullin and alpha-CGRP increase the endothelial [ Ca2+ ] i, activate nitric oxide synthase and release nitric oxide, without a direct inhibitory action on smooth muscle