Hama et al., Biochem Biophys Res Commun 2006
(Fibrosis) :
We demonstrated that Ang II inhibited TGF-beta1 induced nuclear accumulation of Smad3 and Smad4 Zhang et al., Hypertension 2010
(Fibrosis...) :
Enhanced upregulation of the Ang II type I receptor and activation of the transforming growth factor-beta/Smad and nuclear factor-kappaB signaling pathways may be the mechanisms by which CRP promotes cardiac fibrosis and inflammation under high Ang II conditions