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MAPKAP1 — TSC2

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC2/DEPTOR complex (MTOR-MLST8-MAPKAP1-DEPTOR-RICTOR-PRR5) → TSC1/TSC2 complex (TSC1-TSC2) (modification, collaborate)
  Huang et al., Mol Cell Biol 2008, Peterson et al., Cell 2009
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Huang et al., Mol Cell Biol 2008 : However, how mTORC2 is regulated and whether the TSC1-TSC2 complex is involved are unknown ... Our data also suggest that the TSC1-TSC2 complex positively regulates mTORC2 in a manner independent of its GTPase activating protein activity toward Rheb ... These data demonstrate that the TSC1-TSC2 complex inhibits mTORC1 and activates mTORC2 , which through different mechanisms promotes Akt activation
Melnik et al., Exp Dermatol 2013 : Antiandrogens may attenuate mTORC1 by suppressing mTORC2 mediated Akt/TSC2 signalling