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IRF6 — ZFP36

Text-mined interactions from Literome

Mahtani et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : The zinc finger protein tristetraprolin (TTP) is expressed in response to LPS and regulates the stability of TNF-alpha mRNA ... We show that stimulation of RAW264.7 mouse macrophages with LPS induces the binding of TTP to the TNF-alpha 3 ' untranslated region
Zhang et al., Biochem Soc Trans 2002 : Whereas TIAR and TIA-1 bind the TNF-alpha ARE independently of the activation state of macrophages, the TTP-ARE complex is detectable upon stimulation with lipopolysaccharide (LPS)
Brooks et al., J Immunol 2004 (MAP Kinase Signaling System) : Using pharmacologic inhibitors of the mitogen activated protein kinase pathways, we show that the induction of TTP by LPS activation is mediated through changes in transcription, mRNA stability, and translation
Chen et al., Biochem Biophys Res Commun 2006 : Electrophoretic mobility shift assays showed that the LPS induced destabilization factor tristetraprolin (TTP) could bind to TNFalpha ARE with higher affinity than to IL-1beta ARE
Cao et al., J Nutr 2008 (Inflammation) : TTP expression is reduced in fats of obese people with metabolic syndrome and brains of suicide victims and is induced by insulin and cinnamon polyphenol extract (CPE) in adipocytes, by lipopolysaccharide (LPS) in macrophages, and by green tea polyphenol extract in rats ... LPS ( 0.1 mg/L, 4 h ) increased TTP , TNF, granulocyte-macrophage colony stimulating factor, cyclooxgenase-2, and interleukin 6 mRNA levels by 39-1868 fold
Huotari et al., APMIS 2012 (MAP Kinase Signaling System) : TTP and MKP-1 expression was increased by cytokines or LPS
Chen et al., Mol Biol Rep 2013 : Tristetraprolin (TTP) , which is an mRNA destabilizing protein that negatively regulates the expression of pro-inflammatory mediators, is induced by LPS ... To delineate the molecular mechanism of LPS stimulated TTP expression, several inhibitors blocking different signaling pathways were used initially
Hochdörfer et al., Cell Signal 2013 : LPS treatment also induced p38 dependent expression of the TTP gene