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IL10 — PIK3CA

Text-mined interactions from Literome

Williams et al., J Immunol 2004 (Disease Susceptibility...) : Inhibition of PI3K resulted in increased serum levels of IL1-beta, IL-2, IL-6, IL-10 , IL-12, and TNF-alpha in septic mice
Merck et al., Blood 2005 : A PI3K dependent up-regulation of IL-10 release is observed with all the TLR ligands used, whereas regulation of IL-12 production is variable depending on the TLR stimulated
Rahimi et al., J Immunol 2005 : IL-10 induced the phosphorylation of PI3K and p42/44 ERK MAPK
Saegusa et al., Mol Immunol 2007 : A specific ERK inhibitor, U0126, as well as PI3K inhibitors, differentially regulated IL-10 and IL-12 p70 productions ... These results suggest that PI3K positively and negatively regulates the production of CpG-ODN induced IL-10 and IL-12 p70, respectively, and negatively regulates IL-12 p70 production in macrophages through ERK mediated IL-10 induction
Lambert et al., J Immunol 2007 : To test the hypothesis that PI3K , which acts upstream of mammalian target of rapamycin, might also be involved in LMP1 dependent IL-10 production, we generated B cell lines expressing signaling-inducible chimeric LMP1 ... Our results show that induced LMP1 signaling elicits both p38- and PI3K dependent IL-10 production in EBV- B cells ... We also demonstrate that the LMP1 dependent p38 and PI3K activation regulates IL-10 induction through discrete mechanisms
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Hoarau et al., PloS one 2008 (Hypersensitivity...) : We found that 1 ) the PI3K pathway was positively involved in the prolonged DC survival induced by BbC50sn, LPS and Zymosan in contrast to p38MAPK and GSK3 which negatively regulated DC survival ; 2 ) p38MAPK and PI3K were positively involved in DC maturation, in contrast to ERK and GSK3 which negatively regulated DC maturation ; 3 ) ERK and PI3K were positively involved in DC-IL-10 production, in contrast to GSK3 that was positively involved in DC-IL-12 production whereas p38MAPK was positively involved in both ; 4 ) BbC50sn induced a PI3K/Akt phosphorylation similar to Zymosan and a p38MAPK phosphorylation similar to LPS
Garcia et al., J Immunol 2009 : In the present study, we demonstrate that IL-12p70 induces IL-10 production from human memory CD4+ T cells via a PI3K dependent signaling mechanism ... Inhibition of PI3K prevented the inactivation of GSK3beta by IL-12p70, as well as the subsequent ability of IL-12p70 to augment IL-10 levels by memory CD4+ T cells
Dutra et al., Br J Pharmacol 2011 (Colitis) : Importantly, the PI3K? inhibitor also up-regulated IL-10 , CD25 and FoxP3 expression
Antoniv et al., Immunology 2011 : Phosphatidylinositol 3-kinase (PI3K) -mediated signalling regulates inflammatory responses and can induce IL-10 production, but a role for PI3K signalling in cellular responses to IL-10 is not known
Gentle et al., J Immunol 2012 : Modulation required de novo protein synthesis, and PI3K, JNK, and ERK activity were necessary for enhanced IL-2 expression, whereas modulation of IL-10 required only PI3K activity
Hatton et al., PloS one 2012 (Lymphoma, B-Cell) : Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes Syk to activate PI3K/Akt signaling and induce IL-10 production
Tapia-Abellán et al., Liver Int 2013 (Liver Cirrhosis) : The release of the pro-inflammatory cytokines IL-6 and TNF-a at baseline was more effectively reduced by the MAPK inhibitors, while the basal IL-10 anti-inflammatory cytokine secretion was only and strongly ( 90.3 % ) affected by the PI3K inhibitor ... Finally, inhibition of PI3K almost completely suppressed the secretion of IL-10 in stimulated M-DM
Bavelloni et al., J Cell Sci 1999 (Osteosarcoma) : Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells