Ouchida et al., J Immunol 2010
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These results demonstrate a role for LAPTM5 in the negative regulation of cell surface BCR levels and B cell activation
Kawano et al., Mol Cell Biol 2012
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Here we demonstrate that the pre-BCR signal induces the expression of lysosome associated protein transmembrane 5 ( LAPTM5 ), which leads to the prompt downmodulation of the pre-BCR ... Notably, the LAPTM5 deficiency in pre-B cells led to the augmented expression level of surface pre-BCR