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CDK2 — MNAT1

Pathways - manually collected, often from reviews:

• Reactome Reaction: MNAT1 → CDK2 (reaction) Aprelikova et al., J Biol Chem 1995

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MNAT1 — CDK2 (physical association, affinity chromatography technology) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of 30 proteins (association, tandem affinity purification) Varjosalo et al., Nat Methods 2013
• IRef Intact Interaction: Complex of MNAT1-CDK7-CCNH-CDK2 (phosphorylation reaction, protein kinase assay) Tassan et al., EMBO J 1995*

Text-mined interactions from Literome

Morisaki et al., Exp Cell Res 1999 : This cyclin D1-bound Cdk2 was not activated by CAK either in vivo or in vitro, implicating cyclin D1 as an inhibitor of Cdk2 activation
Kim et al., J Biol Chem 2001 : For example, CDK9 was not phosphorylated by CAK, whereas CDK2-cyclin A kinase activity was dramatically enhanced by CAK
Yao et al., Mol Cell Biol 2002 : Activation of the Bur1-Bur2 cyclin dependent kinase complex by Cak1
Hamada et al., Biochim Biophys Acta 1996 : Phorbol ester treatment does not reduce the protein level of p33CDK2 , but does inhibit serum stimulated increases in the CAK activity and CDK2 phosphorylation at Thr160
Mandal et al., Oncogene 1998 : We also demonstrated that IFN induced CKIs prevent CAK from activating the CDK-2 as immunodepletion of induced CKIs from the inhibitory extracts resulted in the restoration of CAK mediated activation of CDK-2