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IL17A — MMP13

Text-mined interactions from Literome

Koshy et al., Ann Rheum Dis 2002 : IL17 can, alone and synergistically in combination with other proinflammatory cytokines, promote chondrocyte mediated MMP dependent type II collagen release from cartilage
Bamba et al., J Gastroenterol 2003 : In human colonic SEMFs, MMP-3 secretion and MMP-3 mRNA expression were induced by IL-17 , IL-1beta, and TNF-alpha
Sylvester et al., Cell Signal 2004 : ERK pathway inhibitors, PD98059 and U0126, down-regulated IL-17 induced MMP and ADAM-TS4 gene expression
Koenders et al., Arthritis Rheum 2005 (Arthritis, Experimental...) : Moreover, local IL-17 gene transfer increased MMP expression without the need for IL-1, although IL-1 remained essential for part of the cartilage VDIPEN expression
Liacini et al., Arthritis Res Ther 2005 : MMP-3 and MMP-13 gene expression induced by IL-1beta, TNF-alpha and IL-17 was downregulated by mithramycin in human chondrosarcoma SW1353 cells and in primary human and bovine femoral head chondrocytes
Inatomi et al., Pancreas 2007 : In human pancreatic myofibroblasts, MMP-3 secretion and mRNA expression were induced by interleukin (IL)-17 , IL-1beta, and tumor necrosis factor (TNF) -alpha, respectively
Yagi et al., J Gastroenterol 2007 (Colitis) : IL-17A and IL-17F significantly enhanced IL-6, IL-8, LIF, MMP-1 , and MMP-3 secretion ... Both IL-17A and IL-17F augmented IL-1beta induced secretion of IL-6, IL-8, LIF, MMP-1 , and MMP-3
Agarwal et al., J Rheumatol 2008 (Arthritis, Rheumatoid...) : Increased IL-17 levels in ERA SF correlate with disease activity and this may be due to increased production of MMP and cytokines by IL-17
Wang et al., Cancer Biol Ther 2013 (Bone Neoplasms...) : We observed that IL-17A/IL-17RA interaction promoted the expression of VEGF, MMP9 and CXCR4 in OS cells, which might partly explain the enhanced metastasis of OS cells
Wu et al., J Endod 2013 : This study aimed to investigate the effects of interleukin (IL)-17 on the mRNA expression and protein production of MMP-1, MMP-2, MMP-9, MMP-13 , TIMP-1, and EMMPRIN through human periodontal ligament cells ... IL-17 significantly up-regulated MMP-1 and MMP-13 mRNA expression but down-regulated MMP-2, MMP-9, and TIMP-1 mRNA expression ... Furthermore, IL-17 ( 50 ng/mL ) increased the secreted protein level of MMP-1 and MMP-13 and conversely reduced the level of MMP-2, MMP-9, and TIMP-1
Hayata et al., PloS one 2013 (Melanoma, Experimental...) : Inhibition of IL-17A at tumor sites significantly suppressed CD31, MMP9 , and VEGF expression in tumor tissue
Xie et al., PloS one 2013 : Moreover, in cultured cardiac fibroblasts, IL-17A induced the expression of ADAMTS-1, MMP-2 , and collagen subtypes I and III and increased the proliferation of fibroblasts