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EPHB2 — TFRC
Text-mined interactions from Literome
Sauer et al., FASEB J 2001
(MAP Kinase Signaling System...) :
The radical scavengers vitamin E, dimethyl thiourea ( DMTU ), and N-acetyl cysteine (NAC) failed to
inhibit ERK1/2 activation but abolished
p90 ribosomal S6 kinase (p90RSK) activation downstream of ERK1/2, as well as the growth stimulation of tumor spheroids
Goulet et al., Carcinogenesis 2005
:
Furthermore, the phosphorylation of p90RSK and histone H3 were both antagonized by the MEK inhibitor U0126, implying that SeMet induced phosphorylation of
p90RSK and histone H3 are at least in part
ERK pathway
dependent
Rolfe et al., Biochem J 2005
:
This phosphorylation may be mediated by
p90RSK ( 90 kDa ribosomal protein S6K ), which is
activated by
ERK , and appears to involve phosphorylation at Ser1798
Itoh et al., J Biol Chem 2005
:
We found that the inhibition of
p90RSK prevented H2O2 mediated cTnI ( Ser ( 23/24 ) ) phosphorylation but not
ERK1/2 and PKCalpha/betaII activation
Samuel et al., J Neurochem 2008
:
The activated
ERK1/2 then
induced a sequential activation of
p90RSK , and increase in phosphorylation of transcription factors c-fos and c-jun leading to transcriptional activation of AP-1
Calzolari et al., Blood Cells Mol Dis 2009
(Carcinoma...) :
In colon cancer cell lines,
TfR2 is localized in membrane lipid rafts,
induces ERK1/ERK2 phosphorylation, when activated by its ligand transferring, and is preferentially expressed during S-M phases of the cell cycle
Le et al., Circulation 2013
(Atherosclerosis...) :
When activated,
p90RSK associated with ERK5, and this association
inhibited ERK5 transcriptional activity and upregulated vascular cell adhesion molecule 1 expression
Guo et al., Zhong Yao Cai 2012
(Brain Ischemia...) :
TFR ( 30, 60 mg/kg ) could
increase the activation of
ERK1/2 after cerebral ischmia-reperfusion