◀ Back to EPHB2

CNTF — EPHB2

Text-mined interactions from Literome

Dziennis et al., J Biol Chem 2003 (Neuroblastoma) : Preventing ERK activation with PD98059 blocked CNTF suppression of DBH protein in sympathetic neurons but did not prevent the loss of DBH mRNA
Rhee et al., J Neurosci 2004 : In contrast, CNTF causes preferential phosphorylation of ERK in progenitor cells and photoreceptor precursors ... Inhibition of the cytokine receptor gp130 using neutralizing antibodies reveals that gp130 is required for both CNTF induced STAT3 and ERK phosphorylation
Goureau et al., Dev Neurosci 2004 : Perturbation of STAT and ERK signaling using protein kinase inhibitors and a dominant negative STAT3 mutant demonstrates that both CNTF induced STAT and ERK activation are involved in promoting Muller cell production
de Melo Reis et al., Brain Res 2008 : Murine Müller glial conditioned medium ( MMG ) was concentrated and at 1 : 1 dilution supported 100 % survival of chick or rat sympathetic neurons after 48 h compared to < 5 % in controls. Partial purification of the MMG using centriprep concentrators showed that trophic activity is from molecules above 10 kDa. MMG stimulated AKT, ERK and pStat3 in sympathetic neurons. Sympathetic or DRG neuronal survival induced by MMG was blocked by anti-human NGF, but not by anti-human CNTF ( sympathetic ) or by anti-BDNF ( DRGs ) neutralizing antibodies. MMG also induced neurite outgrowth in P4 mice retinal explants and on isolated RGC. RGCs plated on top of Müller glia cells had a much better survival rate ( > 80 %, 96 h ) compared to laminin+poly-L-lysine substrates
Sango et al., Histochem Cell Biol 2008 : Western blot analysis revealed that CNTF induced phosphorylation of STAT3, Akt, and ERK1/2 in the neurons
Rhee et al., Adv Exp Med Biol 2010 : CNTF/LIF activates Jak-STAT, ERK , and Notch pathways during retinal development
Li et al., PloS one 2011 : Exogenous CNTF , CT1, or OsM induces STAT3 phosphorylation, and OsM also induces the phosphorylation of ERK1/2 ( p44/42 MAP kinase )