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IRF6 — LPO
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Cheng et al., Shock 2005
:
Lead ( Pb ) increases
lipopolysaccharide (LPS) induced tumor necrosis factor-alpha (TNF-alpha), nitric oxide ( NO ),
lipid peroxidation (LPO) , and liver damage ... Pb +
LPS coexposure significantly
increased phosphorylation of p42/44 MAPK and TNF-alpha expression in peripheral blood cells ; however, exposure to Pb + LPS did not induce TNF-alpha, NO, or
LPO production and p42/44 MAPK activation in the liver
Escames et al., Exp Gerontol 2006
(Endotoxemia...) :
An age dependent increase in iNOS activity, NO content, and
LPO levels was observed, and these changes were
augmented further by
LPS
Sewerynek et al., J Physiol Pharmacol 2011
:
We have found that
LPS induces
LPO in tissue homogenates in vitro in a concentration dependent manner, the concentration of 400 µg/ml demonstrating the most efficient lipid damaging effect ... The aim of our study was to compare the effects of melatonin (MEL) and indole compound : 6-methoxytryptophol, on
LPS induced
LPO in vitro ... In all the examined tissues,
LPS stimulated
LPO , while both melatonin and 6-methoxytryptophol released LPS stimulated LPO