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GNRH1 — IRF6

Text-mined interactions from Literome

Feleder et al., Exp Clin Endocrinol Diabetes 2000 : In adult animals, LPS induced a significant inhibition ( 50 % of basal values ) of LHRH release, accompanied by an increase in GABA and taurine output ... Our results demonstrate the existence of age related differences in the effect of LPS on LHRH and gonadotropin secretion
Watanobe et al., Endocrinology 2003 : LPS inhibited the secretion of both LH and GnRH and concomitantly stimulated the release of all three cytokines ... These results strongly suggest that IL-1 beta and TNF-alpha may represent the major proinflammatory cytokines mediating the LPS induced suppression of GnRH and LH release, whereas the role of IL-6 seems to be insignificant
Feleder et al., Neuroimmunomodulation 1996 : These observations indicate that LPS inhibits LHRH and glutamate release, but stimulates taurine and GABA secretion
Nappi et al., Endocrinology 1997 : Interestingly, LPS caused a profound down-regulation of LHRH-R gene expression in the anterior pituitary throughout the entire estrous cycle
Yoo et al., Endocr J 1997 : These results suggest that LPS leads to the suppression of gonadotropin releasing hormone pulse generator activity through a mechanism involving TNF-alpha
Feleder et al., Neuroimmunomodulation 1996 : Then, knowing that gamma-aminobutyric acid ( GABA ) mediates other neurotransmitter effects in the central nervous system, the possibility arises that this amino acid might mediate the effect of LPS on LHRH release by modifying amino acid neurotransmitter release at the hypothalamic level ... Therefore, the present study was designed to investigate a possible mediatory function of the GABAergic system in the LPS induced inhibition of LHRH secretion ... The GABA antagonists blocked and reversed the LPS effect on LHRH secretion
Feleder et al., Biol Signals Recept 1998 : LPS inhibition of LHRH release at hypothalamic level appears to be associated with modifications in the cerebral immune system ... IL-6ra significantly ( p < 0.01 ) potentiated the inhibitory effect of LPS on LHRH secretion ... These results could indicate that IL-6 partly attenuates the inhibitory effect of LPS on LHRH release ... These data suggest that the inhibitory effect of LPS on LHRH release may be explained by the stimulation of other cytokines than IL-6, meanwhile the augmented levels of IL-6 probably released via a nonneuronal source was shown to be higher when LHRH was decreased