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CDKN1A — PARP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CDKN1A
—
PARP1
(colocalization, imaging technique)
Bursać et al., Proc Natl Acad Sci U S A 2012
-
IRef Biogrid Interaction:
CDKN1A
—
PARP1
(direct interaction, pull down)
Frouin et al., J Biol Chem 2003*
-
IRef Biogrid Interaction:
CDKN1A
—
PARP1
(direct interaction, pull down)
Cazzalini et al., DNA repair 2010*
-
IRef Biogrid Interaction:
CDKN1A
—
PARP1
(physical association, affinity chromatography technology)
Cazzalini et al., DNA repair 2010*
-
IRef Biogrid Interaction:
CDKN1A
—
PARP1
(physical association, affinity chromatography technology)
Lee et al., Molecular cancer 2010*
-
IRef Hprd Interaction:
CDKN1A
—
PARP1
(in vitro)
Frouin et al., J Biol Chem 2003*
-
IRef Hprd Interaction:
CDKN1A
—
PARP1
(in vivo)
Frouin et al., J Biol Chem 2003*
-
IRef Ophid Interaction:
CDKN1A
—
PARP1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Frouin et al., J Biol Chem 2003
:
Unexpectedly,
PARP-1 activity also decreased in the
presence of
p21waf1/cip1
Rosato et al., Mol Pharmacol 2004
:
Enforced expression of
p21 ( WAF1/CIP1 ) ( i.e., in Jurkat cells inducibly expressing p21 ( WAF1/CIP1 ) under the control of a doxycycline-responsive promoter ) partially but significantly
reduced cytochrome c and apoptosis inducing factor release, loss of mitochondrial membrane potential, caspase-3 and -8 activation, Bid cleavage, poly ( ADP-ribose ) polymerase (
PARP ) degradation, and apoptosis in response to SB/FP
Li et al., J Biol Chem 2005
:
Both
p21 ( waf1/cip1 ) antisense and small interfering RNA could
restore apoptotic associated caspase 3 activity,
PARP activation, and sensitivity to mitomycin induced apoptosis
Madison et al., Oncogene 2010
:
PARP inhibition
attenuated activation of
p21 transcription by both p53 independent and p53 dependent processes, in a CtBP dependent manner