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DUOX2 — STAT1
Text-mined interactions from Literome
Wu et al., J Biol Chem 2011
:
Up-regulation and sustained activation of
Stat1 are
essential for interferon-gamma (IFN-gamma) induced
dual oxidase 2 (Duox2) and dual oxidase A2 (DuoxA2) expression in human pancreatic cancer cell lines
Wu et al., J Immunol 2013
(Chronic Disease...) :
We recently demonstrated that
dual oxidase (Duox)2 , an NADPH oxidase essential for reactive oxygen species related, gastrointestinal host defense, is
regulated by IFN-? mediated
Stat1 binding to the Duox2 promoter in pancreatic tumor lines ... Induction of
Duox2 expression by IFN-? and LPS may
result from IFN-? related activation of
Stat1 acting in concert with NF-?B related upregulation of Duox2