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IL13 — IL13RA1

Pathways - manually collected, often from reviews:

• KEGG Cytokine-cytokine receptor interaction: IL13 → Complex of IL13RA1-IL4R (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: IL13RA1 — IL13 (direct interaction, surface plasmon resonance) Lupardus et al., Structure 2010*
• IRef Dip Interaction: IL13RA1 — IL13 (direct interaction, isothermal titration calorimetry) Lupardus et al., Structure 2010*
• IRef Dip Interaction: IL13RA1 — IL13 (direct interaction, cross-linking study) Aman et al., J Biol Chem 1996*
• IRef Hprd Interaction: IL13RA1 — IL13 (in vivo) Oshima et al., J Biol Chem 2001*
• IRef Innatedb Interaction: IL13RA1 — IL13 (unknown, -) Miloux et al., FEBS Lett 1997
• IRef Intact Interaction: IL13RA1 — IL13 (physical association, molecular sieving) LaPorte et al., Cell 2008*
• IRef Intact Interaction: IL13RA1 — IL13 (direct interaction, isothermal titration calorimetry) LaPorte et al., Cell 2008*
• IRef Intact Interaction: Complex of 13 proteins (direct interaction, x-ray crystallography) LaPorte et al., Cell 2008*
• IRef Ophid Interaction: IL13RA1 — IL13 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Myrtek et al., Immunology 2004 : Whereas IL-13 and IL-4 had inhibitory effects on IL-13Ralpha1 expression on eosinophils, interferon-gamma, tumour necrosis factor-alpha, and, to the largest extent, transforming growth factor-beta, enhanced the expression of this receptor subunit
Finkelman et al., J Immunol 2005 (Bronchial Hyperreactivity) : Although IL-4 signals through two receptors, IL-4R alpha/common gamma-chain ( gamma(c) ) and IL-4R alpha/IL-13R alpha1 , and only the latter is also activated by IL-13 , IL-13 contributes more than IL-4 to goblet cell hyperplasia and airway hyperresponsiveness in murine asthma
Kasaian et al., Biochem Pharmacol 2008 (Asthma...) : On B cells, monocytes, epithelial cells, and smooth muscle cells, IL-13 acts through the IL-13Ralpha1/IL-4Ralpha complex to directly induce activation responses that contribute to atopic disease