◀ Back to ARF6
ARF6 — SLC2A4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Arf6 trafficking events:
GLUT4 (SLC2A4)
→
ARF6/GTP complex (ARF6)
(modification, collaborate)
Li et al., J Cell Biol 2007*
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database Arf6 trafficking events:
ARF6/GTP complex (ARF6)
→
GLUT4/clathrin heavy chain/ACAP1 complex (ACAP1-CLTC-SLC2A4)
(modification, activates)
Li et al., J Cell Biol 2007*
Evidence: mutant phenotype, physical interaction, other species
-
WikiPathways Insulin Signaling:
STXBP2/CYTH3/KIF5B/EHD2/ARF6/RAB4A/CAP1/STXBP1/CRK/STXBP4/TBC1D4/SH2B2/EHD1/ARHGAP33/STX4/SNAP25/RHOQ/SNAP23/CBLB/STXBP3/CBL/FLOT2/CBLC/MYO1C/RHOJ/SORBS1/ARF1/RAPGEF1/VAMP2/FLOT1/KIF3A
→
SLC2A4
(activation)
Text-mined interactions from Literome
Millar et al., J Biol Chem 1999
:
These data suggest an important
role for
ARF6 in regulating cell surface levels of
GLUT4 in adipocytes, and argue for a role for both ARF5 and ARF6 in the regulation of membrane trafficking to the plasma membrane
Bose et al., Mol Cell Biol 2001
:
Remarkably, expression of a dominant inhibitory form of the actin-regulatory GTPase
ARF6 [ ARF6 ( T27N ) ] in cultured adipocytes selectively
inhibited both F-actin formation and
GLUT4 translocation in response to endothelin 1 but not insulin
Lawrence et al., Mol Cell Biol 2001
:
However, the same
ARF6 inhibitory mutant
blocked the stimulation of hexose uptake and
GLUT4 translocation in response to either endothelin 1 or an activated form of Galphaq, Galphaq ( Q209L )