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ANGPT2 — CASP2
Text-mined interactions from Literome
Foo et al., J Cell Physiol 2006
(Hypertrophy) :
Our findings demonstrate that
Ang II ( 100 nM, 24 h ) alone
upregulates HO-1 expression and induces both myocyte hypertrophy and apoptosis, assessed by measuring terminal deoxynucleotidyltransferase dUTP nick-end labelling ( TUNEL ) staining,
caspase-3 activity and mitochondrial membrane potential
Eley et al., Am J Physiol Endocrinol Metab 2008
(Muscular Atrophy) :
These results suggest that TNF-alpha/IFN-gamma and
ANG II induce muscle protein degradation by a common signaling pathway, which is attenuated by HMB, and that this
involves the initial activation of
caspase-3 and -8 , followed by autophosphorylation and activation of PKR, which then leads to increased ROS formation via activation of p38 MAPK
Tan et al., Circ Res 2009
(Carotid Artery Injuries...) :
Ang II increased SMC apoptosis in an Ang II type 2 receptor-,
caspase 8-, and FasL dependent fashion
Ren et al., Journal of biomedical research 2012
:
Specifically,
angiopoietin-1 prevented DOX induced increases in FasL and Bax levels and cleaved
caspase-3 and caspase-8 levels in H9C2 cells