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CCND1 — PTGS2
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Wu Chen et al., Brain Res Mol Brain Res 2004
(Disease Models, Animal...) :
Cyclooxygenase-2 activity
contributes to neuronal expression of
cyclin D1 after anoxia/ischemia in vitro and in vivo ...
COX-2 activity is known to induce expression of cyclin D1 in neoplastic cells, and
cyclin D1 expression can
induce cell death in postmitotic neurons ... These results show that
COX-2 activity is
required for
cyclin D1 expression after ischemia in vivo and anoxia in vitro
Luo et al., J Pharmacol Exp Ther 2007
:
The continued increase of
COX-2 ( up to 18 h )
resulted in increased intracellular prostaglandin E ( 2 ) and
cyclin D1 expression significantly after 8 and 12 h of EGF treatment ... Dexamethasone substantially reduced EGF stimulated
COX-2 expression at 3 and 6 h and
cyclin D1 expression at 8 and 12 h. Pretreatment of RGM-1 cells with dexamethasone or 2'-amino-3'-methoxyflavone ( PD98059 ) -mitogen activated protein kinase kinase inhibitor ( 5 x 10 ( -5 ) M ) significantly
reduced EGF stimulated pERK1/pERK2 expression
Li et al., Neurochem Res 2008
(Hypoxia, Brain) :
Overexpression of
COX-2 did not
increase expression of
cyclin D1 or phosphoretinoblastoma protein (pRb), or cleavage of caspase 3 suggesting that this cell cycle mechanism does not mediate COX-2 toxicity in this model
Sheng et al., Cell Growth Differ 1997
:
Taken together, the results demonstrate that TGF-beta 1 strongly induces COX-2 at both the mRNA and protein levels and suggest that this induction of
COX-2 is
involved in the down-regulation of
cyclin D1 and inhibition of cell growth caused by TGF-beta 1 in rat intestinal epithelial cells