Gene interactions and pathways from curated databases and text-mining

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PLG — PTGS2

Text-mined interactions from Literome

Perchick et al., Endocrinology 2003 (Neovascularization, Pathologic) : Cyclooxygenase-2 overexpression inhibits cathepsin D-mediated cleavage of plasminogen to the potent antiangiogenic factor angiostatin
Simeone et al., Int J Oncol 2007 (Breast Neoplasms...) : Activity of the urokinase-type plasminogen activator ( uPA ) was increased in MCF-7 cells by COX-2 overexpression or by the addition of a PKC activator or by IL-8
Zhang et al., J Immunol 2007 : Interaction of plasmin with annexin A2 resulted in the stimulation of ERK1/2 and p38 MAPK, cyclooxygenase-2 , and PGE ( 2 ), leading to increased MMP-1 production