Midwood et al., Nat Med 2009
(Arthritis) :
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
Liu et al., Mol Cells 2012
(Atherosclerosis) :
Tenascin-C produced by oxidized LDL stimulated macrophages increases foam cell formation through Toll-like receptor-4 ... Taken together, we have identified that TNC produced by oxLDL stimulated macrophages increases foam cell formation through TLR4 and scavenger receptor CD36
Fujimoto et al., Neurobiol Dis 2013
(Disease Models, Animal...) :
LPS-RS blocked TNC induced TLR4 upregulation, JNK and p38 activation, and vasoconstrictive effects ... SP600125 and SB203580 abolished TNC induced TLR4 upregulation and vasoconstrictive effects