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FOS — MMP1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Wenk et al., J Biol Chem 1999
:
Collectively, we have found that enhanced Mn-SOD activity, via an unbalanced H ( 2 ) O ( 2 ) overproduction and detoxification, induces
MMP-1 mRNA levels, and this effect is at least partly
mediated by the DNA recognition sequence
AP-1
Barchowsky et al., Cytokine 2000
(MAP Kinase Signaling System) :
We have reported previously that NF-kappaB and
AP-1 cooperate to
mediate IL-1 induced
MMP-1 transcription
Maldonado et al., Immunology 2003
:
The mutation study further indicated that the
activator protein-1 (AP-1) ( -3471 ) or Ets ( -3836 ) motifs in this distal region were
essential for the LDL-IC stimulated
MMP-1 expression ... In conclusion, the present study shows that both the distal and proximal
AP-1 and Ets motifs are
required for LDL-IC stimulated
MMP-1 expression in U937 histiocytes
Tower et al., Eur J Biochem 2003
:
In this study we demonstrate that the expression of
Fos-like region antigen ( Fra-1 ), an AP-1 transcription factor component that also correlates strongly with neoplastic disease, is
necessary for
MMP-1 transcription in A2058 melanoma cells
Ray et al., Biochim Biophys Acta 2005
(Inflammation...) :
These results show that induction and activation of
AP-1 and SAF-1 transcription factors are
involved in the regulation of
MMP-1 expression in the chondrocytes which could be used as therapeutic targets to combat pathogenesis of OA
Kroczynska et al., Proc Natl Acad Sci U S A 2006
(Mesothelioma) :
Ap-1 activity
caused the expression and activation of
matrix metalloprotease (MMP)-1 and MMP-9, which in turn led to cell invasion
Uhlirova et al., EMBO J 2006
(Disease Models, Animal...) :
JNK- and
Fos regulated
Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila ... This effect requires
Fos dependent transcriptional activation of a matrix metalloprotease gene
mmp1 downstream of JNK
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Cortez et al., Am J Physiol Heart Circ Physiol 2007
:
Inhibition of
AP-1 , NF-kappaB, or C/EBP activation
attenuated IL-17 stimulated
MMP-1 expression
Fréchet et al., Oncogene 2008
(Xeroderma Pigmentosum) :
Deletion analysis revealed the essential
role of
AP-1 activation in constitutive
MMP1 overexpression in XP-C primary fibroblasts
Hasegawa et al., Exp Cell Res 2009
(Neoplasm Invasiveness) :
To assess the role of AP-1 function, we examined the
effects of dominant negative
Fos ( DeltaFos ), BATF and siRNA against c-Jun on
MMP production in v-Crk transformed cells which have augmented production of MMP-2 and MMP-9
Speidl et al., FASEB J 2011
(Plaque, Atherosclerotic) :
In addition, blocking experiments revealed that
MMP-1 expression was
mediated by activation of the transcription factor
AP-1 , and MMP-9 expression was induced by activation of NF-?B and AP-1
Chen et al., Regul Toxicol Pharmacol 2011
:
Taken together, CDP
inhibits UVB induced
MMP-1 expression in skin fibroblasts by suppressing expression of
AP-1 and CYR61 and MCP-1 production
Zhan et al., Exp Cell Res 2012
(Neoplasm Invasiveness...) :
In addition, inhibition of
activator protein-1 (AP-1) reduced
MMP-1 , MMP-9 and MMP-12 gene expression
Westermarck et al., Oncogene 1997
:
These results show that three structurally distinct ETS transcription factors differently modulate
AP-1 dependent upregulation of
MMP-1 gene expression