UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

SRC — ZAP70

Pathways - manually collected, often from reviews:

NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT) → BTK-ITK (ITK/BTK) (modification, collaborate) Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) → BTK-ITK (ITK/BTK) (modification, collaborate) Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Class I PI3K signaling events: None → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, activates) Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → None (modification, activates) Rodriguez et al., Biochem J 2003
Evidence: mutant phenotype, other species
NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) (modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Class I PI3K signaling events: PLC-gamma family (PLCG1/PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species
NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
Evidence: mutant phenotype, physical interaction, other species

Text-mined interactions from Literome

Ottoson et al., J Immunol 2001 : Stimulation of Jurkat T cells with CXCL12 also resulted in ZAP-70 dependent tyrosine phosphorylation of the Src homology 2 domain containing leukocyte protein of 76 kDa ( SLP-76 ) adapter protein
Wiemer et al., J Immunol 2011 : However, Src inhibition, but not PGE ( 2 ) or microtubule inhibition, impaired TCR induced ZAP-70 signaling, demonstrating that T cell stop signal antagonists can function either upstream or downstream of proximal TCR signaling