Wang et al., FASEB J 2009
(MAP Kinase Signaling System) :
In the present study, we demonstrate that CGRP is involved in morphine tolerance by differentially regulating the ERK dependent up-regulation of IL-1beta, TNF-alpha, and microsomal prostaglandin E synthase-1 ( mPGES-1 ) in astrocytes and p38 dependent up-regulation of IL-6 in microglia in the rat spinal cord
Galán et al., J Hypertens 2011
:
Inhibition of either p38 MAPK ( SB203580 ) or ERK1/2 ( PD98059 ) reduced COX-2 and mPGES-1 expression in cells treated with IL-1ß or the combination of IL-1ß and Ang II