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CNP — EPHB2

Text-mined interactions from Literome

Tokudome et al., Endocrinology 2004 (Cardiomegaly) : CNP attenuated basal and ET-1 augumented protein synthesis, atrial natriuretic peptide secretion, hypertrophy related gene expression, GATA-4 and MEF-2 DNA binding activities, Ca ( 2+ ) /calmodulin dependent kinase II activity, and ERK phosphorylation
Ozasa et al., Bone 2005 (MAP Kinase Signaling System) : Western blot analysis demonstrated that the level of GC-B, a particulate guanylyl cyclase specific for CNP, was not changed by treatment with FGFs. Conversely, CNP and 8-bromo-cGMP strongly and dose-dependently inhibited the induction of ERK phosphorylation by FGF2 and FGF18 without changing the level of FGFR-3, although they did not affect the phosphorylation of STAT-1
Jerczynska et al., Regul Pept 2009 : CNP almost abolished TNFalpha induced phosphorylation of ERK1/2 but did not affect JNK phosphorylation, indicating that its effect on ERK1/2 was specific