◀ Back to E2F3

E2F2 — E2F3

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: RB1 → Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2 (protein-protein, dissociation)
  
• KEGG Cell cycle: Complex of E2F1-E2F2-E2F3-TFDP1-TFDP2 → CCNE1/CCNE2 (gene expression, expression)
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/CHE-1 complex (RB1-AATF-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Fanciulli et al., FASEB J 2000, Bruno et al., Cancer Cell 2002, Brehm et al., Nature 1998, Magnaghi-Jaulin et al., Nature 1998, Luo et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/DNMT1 complex (RB1-HDAC1-DNMT1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Robertson et al., Nat Genet 2000
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC3/RBBP4 complex (RB1-HDAC3-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Harbour et al., Cell 1999, Chan et al., Nat Cell Biol 2001, Rubin et al., Cell 2005
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Vandel et al., Mol Cell Biol 2001
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Hiebert et al., Genes Dev 1992, Markham et al., EMBO Rep 2006, Bandara et al., Nature 1991, Chellappan et al., Cell 1991, Bagchi et al., Cell 1991, Lees et al., Mol Cell Biol 1993, Kato et al., Genes Dev 1993
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC1 complex (RB1-HDAC1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nicolas et al., Nucleic Acids Res 2001
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/Elf1 complex (RB1-E2F3_E2F2_E2F1-ELF1) → RB1/E2F1-3 complex (RB1-E2F3_E2F2_E2F1) (modification, collaborate)
  Weintraub et al., Nature 1995, Wang et al., Science 1993
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Rubin et al., Cell 2005, Knudsen et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SUV39H1 complex (RB1-SUV39H1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Nielsen et al., Nature 2001, Vandel et al., Mol Cell Biol 2001
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → E2F1-3 (E2F3/E2F2/E2F1) (modification, collaborate) Magae et al., J Cell Sci 1996
  Evidence: assay
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/SPI1 complex (RB1-SPI1-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Konishi et al., Oncogene 1999
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/DP/HDAC3 complex (RB1-HDAC3-E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Lai et al., Mol Cell Biol 1999
  Evidence: physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: RB1/E2F1-3/Elf1 complex (RB1-E2F3_E2F2_E2F1-ELF1) → RB1/E2F1-3/DP complex (RB1-E2F3_E2F2_E2F1-TFDP1) (modification, collaborate)
  Weintraub et al., Nature 1995, Wang et al., Science 1993
• NCI Pathway Database E2F transcription factor network: E2F1-3/DP complex (E2F3_E2F2_E2F1-TFDP1) → RB1/E2F1-3/DP/HDAC1/RBBP4 complex (RB1-HDAC1-RBBP4-E2F3_E2F2_E2F1-TFDP1) (transcription, activates)
  Fabbrizio et al., EMBO Rep 2002, Ohtani et al., Proc Natl Acad Sci U S A 1995, Hurford et al., Genes Dev 1997
  Evidence: mutant phenotype, reporter gene, physical interaction
• WikiPathways Retinoblastoma (RB) in Cancer: Complex of TFDP1-E2F2 → RRM2/DHFR/TYMS/E2F3/TFDP1 (mim-transcription-translation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• Gene Ontology Complexes transcription factor complex: transcription factor complex complex (ATF7IP-GSC-GCM1-MAFB-NKX2-1-NKX2-5-RARG-KLF4-FOXF1-FOXF2-FOXE3-LDB1-ZFHX3-GATA6-SNAI3-FOXH1-KAT5-AHR-EYA3-NFATC2-CRX-MED27-HES6-SKI-XRCC6-ARNTL-SUB1-JUN-SOX17-SCX-DMBX1-TCF4-TCF7-PDLIM1-TFEB-LBX1-TRRAP-NAA16-EPAS1-MGA-PTF1A-HOXD12-MEF2B-TFDP3-TFDP1-HDAC2-YY1-SMAD9-CLOCK-ONECUT3-SMAD5-SMAD6-SMAD7-SMAD1-SMAD2-PRKDC-RCOR2-NHLH2-REL-TBX5-ARNTL2-BSX-HOXA10-HOXB13-MED23-PUS1-TAL1-RBL1-RBL2-MINA-HMGA1-BARX2-LEF1-EP300-PMF1-ARID5A-WWTR1-LMO2-LMO4-TP73-ABT1-CDK2-DKFZp686M216-CREG1-CTNNB1-SOX9-HAND2-SOX2-TEAD2-MYOG-TEAD4-CEBPA-GFI1B-MYOD1-ALX1-NPAS4-TFAP2D-FIGLA-ALX4-ETS1-PROP1-ASCL3-HCLS1-MSX1-MSX2-SRA1-AJUBA-MTA2-SIN3A-POU3F2-POU3F1-BEX1-MLXIPL-NR2E3-PBX2-ANKRD1-E2F6-E2F5-E2F4-E2F3-E2F2-E2F1-E2F8-CREBBP-ATF5-ATF4-POU2F3) Kaspar et al., J Biol Chem 1999, Wang et al., J Biol Chem 1999, Nagpal et al., J Biol Chem 1999, Blixt et al., Genes Dev 2000, Carlberg et al., Mol Cell Biol Res Commun 2000, Bae et al., Development 2000, Cairo et al., Hum Mol Genet 2001, Tutter et al., Genes Dev 2001, Willis et al., J Biol Chem 2002, Bayne et al., Mol Hum Reprod 2004, Schubert et al., J Biol Chem 2004, Han et al., J Mol Biol 2005, Rodriguez et al., EMBO J 2005, Han et al., Nucleic Acids Res 2005, Zhang et al., Mol Cell Biol 2007, Wong et al., Cell 2009, Stevens et al., Immunology 2009, Stefanovic et al., J Cell Biol 2009, Skokowa et al., Nat Med 2012, Ge et al., Cell 1994, Durocher et al., EMBO J 1997, Hogenesch et al., Proc Natl Acad Sci U S A 1998, Hellqvist et al., J Biol Chem 1998, Ryu et al., Nature 1999

Text-mined interactions from Literome

Hyde et al., Invest Ophthalmol Vis Sci 2002 : Although in the normal lens there do not appear to be unique roles for E2F1 that can not be fulfilled by other E2F family members, in the absence of functional pRB proteins, E2F1 is specifically responsible for the increased expression of E2F3a and p19ARF
Li et al., Mol Cell Biol 2003 : Our results indicate specific roles for E2F1 and E2F2 in the induction of E2F target genes, which contribute to efficient expansion and maturation of hematopoietic progenitor cells
Asp et al., Genes Dev 2009 : However, the role , if any, of E2F proteins, and in particular E2f3 , in myogenic differentiation is not well understood
Martinez et al., Mol Cell Biol 2010 : Furthermore, we demonstrate that E2F1 and E2F2 are transcriptionally induced by DNA damage in an E2f3 dependent manner