Higuchi et al., J Pharmacol Sci 2005
:
SOCS3 also suppressed the basal NPY gene transcription
Alcazar et al., Endocrinology 2012
(Inflammation...) :
Thus, our findings not only demonstrate impaired renal function and profibrotic processes but also provide compelling evidence of a SOCS-3 mediated intrinsic renal leptin resistance and concomitant up-regulated NPY expression as an underlying mechanism