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MYC — PI3

Text-mined interactions from Literome

Chen et al., J Biol Chem 2001 : The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 blocked Myc up-regulation in a concentration dependent manner but had no effect on the Epo induced phosphorylation of ERK1 and ERK2
Kobayashi et al., Blood 2003 (Leukemia) : c-myc IRES activation, c-Myc protein expression, and cell cycle progression were all blocked by a phosphatidylinositol 3-kinase (PI3K) inhibitor, LY294002
Spinsanti et al., J Neurochem 2006 : In our hands, activated PI-3-K reduced the stability of c-Myc, because ( i ) the PI-3-K inhibitor, LY294002, prevented the reduction in c-Myc levels induced by MPEP ; and ( ii ) over-expression of AKT promoted c-Myc ubiquitination