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CDK2 — TGFB1

Text-mined interactions from Literome

Gong et al., Cancer Res 2003 (Adenocarcinoma...) : Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells ... Consequently, p21 induction in early G ( 1 ) is critical for TGF-beta 1 inhibition of CDK2 kinase activity
Shi et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004 : Western blot method was used to examine effect of TGF-beta1 on expression of cyclin A, Cyclin D1, CDK2 and CDK4 in G1 phase of cell cycle ... ( 2 ) 2 ng/ml TGF-beta1 could significantly inhibit the production of cyclin A, cyclin D1, CDK2 and CDK4, the protein levels were significantly lower than control group
Chen et al., Molecular vision 2006 : To evaluate the role of cyclin dependent kinase inhibitors p57 and p15 in transforming growth factor (TGF)-beta1 or TGF-beta2 inhibited proliferation of primary cultured human limbal epithelial cells using short interfering RNA ( siRNA )
Ewen et al., Cell 1993 : Cdk2 activity was also suppressed by TGF beta 1 action, but its constitutive expression failed to override a TGF beta 1-induced G1 block
Koli et al., J Biol Chem 1997 (Breast Neoplasms) : TGF-beta1 treatment up-regulated the Cdk inhibitor p21 and induced its association with Cdk2 in MCF-7 cells ; these responses were blocked by the DeltaRII transgene product
Kleeff et al., J Biol Chem 1998 (Pancreatic Neoplasms) : TGF-beta1 caused a delayed but sustained increase in the protein levels of the cyclin dependent kinase inhibitors p15(Ink4B), p21 ( Cip1 ), and p27 ( Kip1 ) and a sustained increase in type I and II TGF-beta receptors ( TbetaRI and TbetaRII ) mRNA and protein levels
Kamesaki et al., J Immunol 1998 (Lymphoma, B-Cell) : This TGF-beta1 mediated induction of p27Kip1 also resulted in an increased association of p27Kip1 with Cdk2 and a decreased Cdk2 kinase activity