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CTNNB1 — PTGS2
Text-mined interactions from Literome
Howe et al., Cancer Res 1999
(Breast Neoplasms...) :
Expression of the inducible prostaglandin synthase cyclooxygenase-2 appears critical for intestinal tumorigenesis resulting from APC mutation, suggesting that
cyclooxygenase-2 might be a transcriptional
target for
beta-catenin/Tcf complexes
Kim et al., Biochem Biophys Res Commun 2002
(Arthritis) :
Beta-catenin regulates expression of
cyclooxygenase-2 in articular chondrocytes ... We investigated in this study the
role of
beta-catenin in the IL-1beta regulation of
COX-2 expression in articular chondrocytes ... Inhibition of
beta-catenin degradation by the treatment of cells with LiCl or proteasome inhibitor
stimulated expression of
COX-2 , indicating that transcriptionally active beta-catenin is sufficient to induce COX-2 expression ... This was demonstrated further by the observation that ectopic expression of transcriptionally competent
beta-catenin stimulated expression of
COX-2
Araki et al., Cancer Res 2003
:
Mutant
beta-catenin expression
up-regulated the
COX-2 promoter activity and the endogenous COX-2 mRNA expression in HuH7, hepatocellular carcinoma cell line, which is partially abrogated by cotransfection with a dominant negative Tcf-4 expression vector ... Although
beta-catenin alone did not
increase COX-2 protein to detectable levels in HuH7 cells, coexpression of both mutant beta-catenin and mutant K-ras increased COX-2 protein expression, which is consistent with the previous reports that K-ras can stabilize COX-2 mRNA
Mori et al., Eur J Cancer Prev 2002
(Cell Transformation, Neoplastic...) :
Expression of these
beta-catenin accumulated crypts (BCAC) is markedly
suppressed by a chemopreventive
cyclooxygenase-2 inhibitor, celecoxib
Liu et al., J Biol Chem 2004
(Colorectal Neoplasms) :
To establish a role for PEA3 to
beta-catenin induced
COX-2 , we transfected RKO cells with beta-catenin and found that beta-catenin increased PEA3 expression
Lee et al., Nucleic Acids Res 2006
:
beta-Catenin , a key transcription factor in the Wnt signal pathway,
activates transcription of
COX-2
Lee et al., Cancer Res 2007
(Adenocarcinoma...) :
Significantly, the cytoplasm expressed RNA intramer reverted the
beta-catenin induced
COX-2 and cyclin D1 mRNA stabilization
Wang et al., Mol Biol Cell 2009
(Carcinoma, Non-Small-Cell Lung) :
These affects were mediated through
COX-2 dependent activation of
beta-catenin signaling and inhibition of apoptosis