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CTNNB1 — MUC1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(physical association, affinity chromatography technology)
Yamamoto et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(physical association, affinity chromatography technology)
Li et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(direct interaction, pull down)
Li et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(direct interaction, pull down)
Li et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(physical association, affinity chromatography technology)
Li et al., J Biol Chem 2001*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(physical association, affinity chromatography technology)
Ren et al., J Biol Chem 2002*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(physical association, affinity chromatography technology)
Schroeder et al., Oncogene 2003*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(physical association, affinity chromatography technology)
Li et al., Mol Cell Biol 1998*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(direct interaction, pull down)
Li et al., Mol Cell Biol 1998*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(direct interaction, pull down)
Li et al., Cancer Biol Ther 2003*
-
IRef Biogrid Interaction:
CTNNB1
—
MUC1
(direct interaction, pull down)
Yamamoto et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
CTNNB1
—
MUC1
(in vitro)
Li et al., J Biol Chem 2001*, Li et al., J Biol Chem 2001*, Ren et al., J Biol Chem 2002*, Li et al., Cancer Biol Ther 2003*, Schroeder et al., Oncogene 2004*, Yamamoto et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
CTNNB1
—
MUC1
(in vivo)
Li et al., J Biol Chem 2001*, Li et al., J Biol Chem 2001*, Ren et al., J Biol Chem 2002*, Li et al., Cancer Biol Ther 2003*, Schroeder et al., Oncogene 2004*, Yamamoto et al., J Biol Chem 1997*
-
IRef Innatedb Interaction:
Complex of CTNNB1-MUC1-MUC1
(unknown, -)
Molock et al., Biochem Biophys Res Commun 2006*
-
IRef Innatedb Interaction:
MUC1
—
CTNNB1
(unknown, -)
Lillehoj et al., Biochim Biophys Acta 2007*
-
IRef Innatedb Interaction:
MUC1
—
CTNNB1
(unknown, -)
Li et al., Biochem Biophys Res Commun 2004*
-
IRef Ophid Interaction:
MUC1
—
CTNNB1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
-
IRef Ophid Interaction:
MUC1
—
CTNNB1
(aggregation, confirmational text mining)
Li et al., J Biol Chem 2001*
Text-mined interactions from Literome
Li et al., J Biol Chem 2001
:
Moreover and in contrast to GSK3 beta, in vitro and in vivo studies demonstrate that c-Src mediated phosphorylation of
MUC1 increases binding of MUC1 and
beta-catenin
Li et al., J Biol Chem 2001
:
The
MUC1 cytoplasmic domain interacts with the c-Src tyrosine kinase and thereby
increases binding of MUC1 and
beta-catenin
Yuan et al., Biochem Biophys Res Commun 2007
:
Downregulation of
MUC1 expression also
induced beta-catenin relocation from the nucleus to the cytoplasm, increased
E-cadherin/beta-catenin complex formation and E-cadherin membrane localization in PANC1 cells
Poh et al., Cancer Res 2009
:
Lack of
Muc1 regulated
beta-catenin stability results in aberrant expansion of CD11b+Gr1+ myeloid derived suppressor cells from the bone marrow ...
MUC1 is a tumor associated mucin and its cytoplasmic tail ( MUC1-CT ) can
regulate beta-catenin to promote oncogenesis ... Given the importance of beta-catenin in hematopoiesis, we hypothesized that the
MUC1 regulation of
beta-catenin is important for MDSC development
Li et al., Mol Cell Biol 1998
(Breast Neoplasms) :
GSK3beta mediated phosphorylation of
MUC1 had no apparent effect on
beta-catenin levels or the transcriptional coactivation function of beta-catenin