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CRTC2 — PRKAA1

Pathways - manually collected, often from reviews:

• WikiPathways AMP-activated Protein Kinase (AMPK) Signaling: Complex of PRKAG3-PRKAA1-PRKAG2-PRKAG1-PRKAB2-PRKAB1-PRKAA2 → CRTC2 (mim-inhibition) Cheng et al., Bioessays 2006, Fu et al., Cell cycle (Georgetown, Tex.) 2008

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PRKAA1 — CRTC2 (direct interaction, enzymatic study) Henriksson et al., Biochem J 2012*

Text-mined interactions from Literome

Yoon et al., Exp Mol Med 2009 : We have previously shown that CRTC2 activity is regulated by AMP activated protein kinase (AMPK) family members ... Taken together, we propose that adiponectin and thiazolidinedione promote the modulation of AMPK dependent CRTC2 activity to influence hepatic gluconeogenesis
Lerner et al., EMBO Rep 2009 : Specifically, glucose regulates hypothalamic CRTC2 activity via AMP activated protein kinase (AMPK) mediated phosphorylation of CRTC2