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ANGPT1 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Clavel et al., Joint Bone Spine 2003
(Arthritis, Rheumatoid...) :
Angiopoietin-1 , a recently discovered growth factor specific for neovascularization, is expressed within the rheumatoid synovium and may be
stimulated by
TNF-alpha
Brown et al., J Biol Chem 2004
(Arthritis, Rheumatoid...) :
Ang-1 expression is up-regulated in
response to
tumor necrosis factor-alpha (TNF-alpha)
Fan et al., Cancer Res 2004
:
Both IL-1beta and
tumor necrosis factor-alpha caused marked down-regulation of
Ang-1 mRNA levels at 4 h with a further decrease observed at 24 h. Using signaling inhibitors, we identified the P38 pathway as the pathway that mediates IL-1beta down-regulation of Ang-1
Kasama et al., Translational research : the journal of laboratory and clinical medicine 2007
(Arthritis, Rheumatoid...) :
Although stimulation with
TNF-alpha or IFN-gamma
had little or no effect on
Ang-1 secretion, costimulation with IFN-gamma plus TNF-alpha dose- and time-dependently diminished secretion of Ang-1 from hOBs
Taura et al., Gastroenterology 2008
(Disease Models, Animal...) :
In primary cultures, activated HSCs express and secrete
angiopoietin 1 more abundantly than quiescent HSCs, and the inflammatory cytokine
tumor necrosis factor-alpha stimulates its expression in an nuclear factor-kappaB dependent manner
Li et al., J Int Med Res 2012
(Hemorrhagic Fever with Renal Syndrome) :
Serum VEGF,
TNF-a and IFN-? levels were significantly elevated, whereas sVEGFR2 and
Ang-1 levels were
reduced , during the acute phase of HFRS