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PDLIM7 — STAT1
Text-mined interactions from Literome
Chatterjee-Kishore et al., EMBO J 2000
:
Expression of the
low molecular mass polypeptide 2 (LMP2) , which
requires Stat1 , has been studied in detail
Richardson et al., J Virol 2003
(Cell Transformation, Viral) :
Latent membrane protein 1 (LMP-1) expression was
sufficient to induce
STAT1 expression, DNA binding, and transcriptional activity ... The increase in STAT1 expression is mediated by the C-terminal activating region 1 ( CTAR-1 ) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IkappaB, demonstrating a role for NFkappaB in
LMP-1 mediated
STAT1 expression
Najjar et al., J Virol 2005
(Burkitt Lymphoma...) :
Taken together, our results clearly show that
LMP1 induced tyrosine phosphorylation of
STAT1 is almost exclusively due to the NF-kappaB dependent secretion of IFNs
McLaren et al., J Gen Virol 2007
:
The post-translational modifications of STAT1 in LCLs have been analysed and an
LMP1 induced
STAT1 DNA binding complex, different from that generated by alpha interferon ( IFN ) stimulation and not involving tyrosine phosphorylation, is demonstrated
Kalim et al., J Immunol 2012
:
Additionally,
LMP7 inhibition
led to reduced
STAT1 phosphorylation and Th1 differentiation