Gene interactions and pathways from curated databases and text-mining

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PDLIM7 — STAT1

Text-mined interactions from Literome

Chatterjee-Kishore et al., EMBO J 2000 : Expression of the low molecular mass polypeptide 2 (LMP2) , which requires Stat1 , has been studied in detail
Richardson et al., J Virol 2003 (Cell Transformation, Viral) : Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity ... The increase in STAT1 expression is mediated by the C-terminal activating region 1 ( CTAR-1 ) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IkappaB, demonstrating a role for NFkappaB in LMP-1 mediated STAT1 expression
Najjar et al., J Virol 2005 (Burkitt Lymphoma...) : Taken together, our results clearly show that LMP1 induced tyrosine phosphorylation of STAT1 is almost exclusively due to the NF-kappaB dependent secretion of IFNs
McLaren et al., J Gen Virol 2007 : The post-translational modifications of STAT1 in LCLs have been analysed and an LMP1 induced STAT1 DNA binding complex, different from that generated by alpha interferon ( IFN ) stimulation and not involving tyrosine phosphorylation, is demonstrated
Kalim et al., J Immunol 2012 : Additionally, LMP7 inhibition led to reduced STAT1 phosphorylation and Th1 differentiation