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CDKN1B — MYC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CCND2-CDK4-CDKN1B
→
MYC
(increases)
Bouchard et al., EMBO J 1999
Evidence: We nowshow that p27 is rapidly and transiently sequestered by cyclin D2-Cdk4 complexesupon activation of Myc and that cyclin D2 is a direct target gene of Myc.
Text-mined interactions from Literome
Donjerković et al., Cell Growth Differ 1999
(Lymphoma, B-Cell) :
CD40L, the calcium chelator 1,2-bis ( 2-aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid-acetoxymethyl ester, and cyclosporin A all prevented anti-IgM induced p27Kip1 accumulation, suggesting that both the decrease in
c-Myc expression and an increase in free calcium are
necessary for
p27Kip1 up-regulation
Chandramohan et al., J Immunol 2004
:
Reciprocal control of Forkhead box O 3a and
c-Myc via the phosphatidylinositol 3-kinase pathway coordinately
regulates p27Kip1 levels
Old et al., Mol Cancer Res 2010
(Cell Transformation, Neoplastic...) :
Skp2 directs
Myc mediated suppression of
p27Kip1 yet has modest effects on Myc-driven lymphomagenesis