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IFNG — TNFSF10

Text-mined interactions from Literome

Sedger et al., J Immunol 1999 : We show that TRAIL is inducible by IFN-gamma , by TNF-alpha, and by infection with human CMV, and has potent antiviral activity in vitro ... CMV infection increased the expression of TRAIL-R1 and -R2, whereas IFN-gamma down-regulated the expression of TRAIL-Rs on uninfected fibroblasts
Shin et al., Cancer Immunol Immunother 2001 (Carcinoma, Hepatocellular...) : IFN-gamma increased the mRNA expression of Fas, TRAIL and caspase-1, and surface Fas was also increased
Shin et al., Int J Cancer 2001 (Carcinoma, Hepatocellular...) : IFN-gamma induces cell death in human hepatoma cells through a TRAIL/death receptor mediated apoptotic pathway ... In particular, IFN-gamma potently increased the mRNA expression of TRAIL in both cell lines
Chou et al., J Immunol 2001 : Cross linking of TRAIL by plate bound rTRAIL receptor, death receptor 4-Fc fusion protein enhanced T cell proliferation and increased IFN-gamma production in conjunction with immobilized suboptimal anti-CD3 stimulation in mouse splenocytes
Yang et al., Cancer Res 2003 (Neuroblastoma) : IFN-gamma also induces TRAIL expression in NB cell lines
Zhang et al., Cell Death Differ 2003 : Blocking TRAIL and CD95L significantly enhance IFN-gamma production in vitro
Hasel et al., Lab Invest 2003 (Chronic Disease...) : Pancreatic stellate cells express TRAIL in vivo and in vitro, and TRAIL expression is enhanced by IFN-gamma
Lee et al., J Neurosci Res 2003 : In astrocytes, the tumor necrosis factor (TNF) related apoptosis inducing ligand ( TRAIL ) expression level was increased by IFN-gamma ... AG490, a JAK inhibitor, blocked TRAIL expression induced by IFN-gamma ... SB203580, a specific p38alpha and p38beta2 MAPK inhibitor, decreased the TRAIL expression induced by IFN-gamma
Tsai et al., Arthritis Rheum 2004 (Lupus Erythematosus, Systemic) : TRAIL engagement selectively activated human CD4, rather than CD8, T cells and augmented IFNgamma production
Clarke et al., EMBO J 2004 (Breast Neoplasms...) : Promoter mapping, chromatin immunoprecipitation and RNA interference reveal that retinoid induced interferon regulatory factor-1 (IRF-1), a tumor suppressor, is critically required for TRAIL induction by both RA and IFNgamma
Park et al., Eur J Biochem 2004 : Western blotting analyses revealed that IFN-gamma dramatically increased the protein levels of interferon regulatory factor (IRF)-1, but not TRAIL receptors ( DR4 and DR5 ) and pro-apoptotic ( FADD and Bax ) and anti-apoptotic factors ( Bcl-2, Bcl-XL, cIAP-1, cIAP-2 and XIAP )
Takeda et al., Blood 2005 : Although inducers of IFN-gamma stimulated TRAIL expression on mature NK cells, our data indicated that constitutive TRAIL expression was a hallmark of immature cytotoxic NK cells
Chen et al., World J Gastroenterol 2005 (Hepatitis B, Chronic) : These findings suggest that upregulation of TRAIL expression may be induced by virus antigen and inflammatory cytokine IFN-gamma
Kemp et al., Blood 2005 (Urinary Bladder Neoplasms) : Whereas neither interferon alpha ( IFN-alpha ) nor IFN-gamma directly induced TRAIL/Apo2L expression by neutrophils, IFN-alpha did stimulate TRAIL gene transcription, and IFN primed neutrophils contained and released more TRAIL/Apo-2L after BCG stimulation than did unprimed neutrophils
Begue et al., Gastroenterology 2006 (Disease Models, Animal...) : Interferon-gamma and TNF-alpha potently induced TRAIL in IEC
Lee et al., Yonsei Med J 2006 : In particular, IFN-gamma induced the highest levels of TRAIL in cultured astrocytes
Lissat et al., Am J Pathol 2007 (Bone Neoplasms...) : Here, we report on the status of caspase-8 expression in tumors from patients with Ewing 's sarcoma, the effect of interferon-gamma on caspase-8 expression and apoptosis, and the role of caspase-8 for TRAIL- and chemotherapy mediated apoptosis in Ewing 's sarcoma
Le Poole et al., Cancer Immunol Immunother 2008 (Inflammation...) : IFN-gamma induced TRAIL expression by DC and LC, and inhibition of TRAIL partially blocked cytotoxic effects
Wang et al., J Immunol 2008 (Carcinoma, Renal Cell...) : Interestingly, TRAIL appears to play a role in tumor recognition by HC/2G-1 in that reactivity was blocked by anti-TRAIL Ab, and soluble TRAIL could enhance IFN-gamma secretion by HC/2G-1 in response to renal tumors
Nguyen et al., Clin Immunol 2009 (Lupus Nephritis) : In vitro, expression of TRAIL , DR4 and DR5 on primary proximal tubular epithelial cells ( PTEC ) was induced by TNFalpha and IFNgamma