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ALOX15 — IL13

Text-mined interactions from Literome

Hashimoto et al., J Rheumatol 2007 (Arthritis, Rheumatoid...) : 15-LOX induced by IL-13 might regulate the production of LXA4 to have an antiinflammatory effect against proinflammatory lipid mediators in inflamed joints
Bhattacharya et al., Tumour Biol 2009 (Adenoma...) : Regulation of 15-LOX-1 expression is achieved at transcription level by global histone acetylation and may also be dependent on GATA-6, IL-4 and IL-13
Hsi et al., Mol Cancer Ther 2011 (Glioblastoma) : In cells lacking the IL-13Ra2 decoy receptor, IL-13 initiates the production of 15-lipoxygenase-1 (15-LOX-1) , which has been implicated in cellular apoptosis ... We hypothesize that in GBM, IL-13 can induce 15-LOX-1 , which regulates cell apoptosis via signaling through PPAR? and that expression of IL-13Ra2 prevents apoptosis and contributes to tumor growth ... Knocking down IL-13Ra2 with short interfering RNA dramatically induces 15-LOX-1 expression, promotes apoptosis, and reduces GBM tumor growth in vivo
Wuest et al., Atherosclerosis 2012 (Atherosclerosis...) : IL-4 and IL-13 also increase the expression of ALOX15 , however, only IL-4 stimulation seems to drive ALOX15 expression to levels higher than the basal expression of ALOX15B