Zhang et al., J Cell Sci 1999
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Furthermore, the strikingly conserved linker region adjacent to the J-domain was important for Csp function in exocytosis, but not for the activation of Hsc70 ATPase Zhang et al., J Biol Chem 2006
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The Csp induced block of CFTR maturation required Hsp70, because a J-domain mutant ( H43Q ) that interferes with the ability of Csp to stimulate Hsp70 ATPase activity relieved the Csp induced block of CFTR maturation
Braun et al., J Biol Chem 1996
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Here we demonstrated that CSP enhances Hsc70 ATPase activity in a dose dependent manner
Chamberlain et al., J Biol Chem 1997
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Mutation of the histidine ( H43Q ) or aspartic acid ( D45A ) residues of this motif reduced the ability of Csp to stimulate the ATPase activity of mammalian Hsc70