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LIPE — TNF

Text-mined interactions from Literome

Laurencikiene et al., J Lipid Res 2007 : Western blot analysis demonstrated that although TNF-alpha per se reduced mainly PLIN protein expression, TNF-alpha in the presence of WP resulted in a pronounced combined reduction of both hormone-sensitive lipase (HSL) and PLIN protein
Lien et al., Endocrinology 2009 : Moreover, pretreatment with inhibitors of iNOS and guanylate cyclase, but not an adenylate cyclase inhibitor, abolished TNF-alpha induced lipolysis and HSL phosphorylation ... In conclusion, short-term TNF-alpha treatment induces lipolysis in 3T3-L1 adipocytes by increasing iNOS expression and NO production, which activates the guanylyl cyclase/cGMP dependent pathway and induces phosphorylation of HSL
Soares et al., Parasitol Int 2010 (Leishmaniasis, Cutaneous) : Moreover, HsL increased nitric oxide ( NO ) and Tumor Nuclear Factor-alpha (TNF-alpha) and decreased Transforming Growth Factor-beta ( TGF-beta ) production in macrophages
Kawasaki et al., Cytotechnology 2010 : HSL activity was also suppressed by TNF-alpha ... In the presence of TNF-alpha , Met, Cys and CysH suppressed the HSL activity
Lee et al., Am J Physiol Endocrinol Metab 2012 (Insulin Resistance) : TNF did not affect perilipin, HSL , or phosphodiesterase-3B mass but paradoxically suppressed adipose tissue triglyceride lipase expression, and this effect was blocked by DEX