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CD28 — GRB2

Pathways - manually collected, often from reviews:

• BioCarta the co-stimulatory signal during t-cell activation: CD28/CD80 complex (CD80-CD28) → GRB2 (modification, activates)
• BioCarta the co-stimulatory signal during t-cell activation: CD28/CD86 complex (CD86-CD28) → GRB2 (modification, activates)
• KEGG T cell receptor signaling pathway: CD28 → GRB2 (protein-protein, activation)
• Reactome Reaction: CD28 → GRB2 (indirect_complex) Schneider et al., Eur J Immunol 1995*, Okkenhaug et al., J Biol Chem 1998*
• Reactome Reaction: CD28 → GRB2 (reaction) Schneider et al., Eur J Immunol 1995*, Okkenhaug et al., J Biol Chem 1998*
• WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection: CD28 → GRB2 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: GRB2 — CD28 Cai et al., Immunity 1995*, Schneider et al., Eur J Immunol 1995*, Kim et al., J Biol Chem 1998*, Okkenhaug et al., J Biol Chem 1998*
• IRef Bind_translation Interaction: GRB2 — CD28 (affinity chromatography technology) Schneider et al., Eur J Immunol 1995*, Kim et al., J Biol Chem 1998*
• IRef Bind_translation Interaction: GRB2 — CD28 (coimmunoprecipitation) Schneider et al., Eur J Immunol 1995*
• IRef Biogrid Interaction: CD28 — GRB2 (direct interaction, pull down) Nunès et al., J Biol Chem 1996*
• IRef Biogrid Interaction: CD28 — GRB2 (direct interaction, pull down) Okkenhaug et al., J Biol Chem 1998*
• IRef Intact Interaction: GRB2 — CD28 (association, coimmunoprecipitation) Cai et al., Immunity 1995*
• IRef Ophid Interaction: GRB2 — CD28 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Gogishvili et al., Eur J Immunol 2008 : Although we did not address the role of Grb2 in CD28 signalling, these results indicate that CD28 can mediate Lck- and Vav1 dependent proliferative signals independently of PI3K
Lahesmaa et al., J Immunol 1995 : Ligation of CD28 , but not other costimulatory molecules, induced the tyrosine phosphorylation of two previously identified Grb2 binding proteins ( pp76 and pp116 )
Okkenhaug et al., J Biol Chem 1998 : Ligation of CD28 , but not tyrosine-phosphorylation, is required for the SH3 mediated binding of Grb2 to CD28