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CCL5 — CCR3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCR3 → CCL5 (increases, CCL5 Activity)
  Evidence: Table 1. Lymphoid chemokine receptors
• KEGG Cytokine-cytokine receptor interaction: CCL5 → CCR3 (protein-protein, activation)
• KEGG Chemokine signaling pathway: CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2 → CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1 (protein-protein, activation)
  
• Reactome Reaction: CCR3 → CCL5 (direct_complex) Combadiere et al., J Biol Chem 1995*, Power et al., J Biol Chem 1995*, Samson et al., Biochemistry 1996*
• Reactome Reaction: CCR3 → CCL5 (reaction) Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Combadiere et al., J Biol Chem 1995*, Power et al., J Biol Chem 1995*, Takami et al., Brain Res Mol Brain Res 1994, Samson et al., Biochemistry 1996*
• WikiPathways Chemokine signaling pathway: CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16 → CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CCL5 — CCR3 (direct interaction, pull down) Daugherty et al., J Exp Med 1996*
• IRef Biogrid Interaction: CCL5 — CCR3 (direct interaction, pull down) Struyf et al., Eur J Immunol 2001*
• IRef Dip Interaction: CCL5 — CCR3 (physical association, biochemical) Combadiere et al., J Biol Chem 1995*
• IRef Dip Interaction: CCL5 — CCR3 (physical association, experimental interaction detection) Umland et al., J Leukoc Biol 2000*
• IRef Hprd Interaction: CCL5 — CCR3 (in vivo) Daugherty et al., J Exp Med 1996*, Pakianathan et al., Biochemistry 1997*
• IRef Innatedb Interaction: CCL5 — CCR3 (unknown, -) Daugherty et al., J Exp Med 1996*
• IRef Ophid Interaction: CCL5 — CCR3 (aggregation, confirmational text mining) Daugherty et al., J Exp Med 1996*
• IRef Ophid Interaction: CCL5 — CCR3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Corbin et al., J Neurovirol 2006 (Nervous System Diseases...) : Additionally, CCR1 deficiency did not affect the up-regulation of its ligands, CCL3, CCL5 , or CCL7
Wang et al., PloS one 2012 (Bone Neoplasms...) : Stimulation of cells with CCL5 increased CCR5 but not CCR1 and CCR3 expression
Long et al., Stem Cells 2012 (Neoplasm Invasiveness...) : Our results suggested that the autocrine activation of CCR1 and CCR3 by CCL5 represents one of major mechanisms underlying the metastatic property of ovarian CSLCs