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NQO1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: NQO1 — TP53 (physical association, affinity chromatography technology) Asher et al., Proc Natl Acad Sci U S A 2003*
• IRef Dip Interaction: NQO1 — TP53 (physical association, coimmunoprecipitation) Anwar et al., J Biol Chem 2003*
• IRef Hprd Interaction: NQO1 — TP53 (in vivo) Anwar et al., J Biol Chem 2003*

Text-mined interactions from Literome

Mirzayans et al., Carcinogenesis 1999 : We conclude that up-regulation of p53 by 4NQO is mediated solely by an ATM independent mechanism and that the p53 response is primarily triggered by persistent alkali-stable 4NQO-DNA adducts
Asher et al., Proc Natl Acad Sci U S A 2001 (Colonic Neoplasms) : Here we show that NADH quinone oxidoreductase 1 (NQO1) regulates p53 stability ... NQO1 inhibition induced p53 degradation and blocked wild-type p53 mediated apoptosis in gamma irradiated normal thymocytes and in M1 myeloid leukemic cells that overexpress wild-type p53
Asher et al., Proc Natl Acad Sci U S A 2002 : NQO1 stabilizes p53 through a distinct pathway ... We now have found that wild-type NQO1 , but not the inactive polymorphic NQO1, can stabilize endogenous as well as transfected wild-type p53 ... NQO1 also partially inhibited p53 degradation mediated by the human papilloma virus E6 protein, but not when mediated by Mdm-2 ... Differences in the effectiveness of dicoumarol and hsp90 inhibitors to induce p53 degradation and suppress apoptosis in these cell types indicate that NQO1 and hsp90 stabilize p53 through different mechanisms
Asher et al., Proc Natl Acad Sci U S A 2002 : We have found another pathway for p53 proteasomal degradation regulated by NAD(P)H quinone oxidoreductase 1 ( NQO1 ) ... This finding indicates that the NQO1 regulated proteasomal p53 degradation is Mdm-2 independent ... Inhibition of NQO1 activity in cells with a temperature-sensitive E1 ubiquitin activating enzyme induced p53 degradation and inhibited apoptosis at the restrictive temperature without ubiquitination
Asher et al., Genes Dev 2005 : Our findings provide the first evidence for in vivo degradation of p53 and p73 by the 20S proteasomes and its regulation by NQO1 and NADH level
Tsvetkov et al., Proc Natl Acad Sci U S A 2005 (Neoplasms) : Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin ... NAD(P)H:quinone oxidoreductase 1 ( NQO1 ) regulates the stability of the tumor suppressor WT p53 ... NQO1 binds and stabilizes WT p53, whereas NQO1 inhibitors including dicoumarol and various other coumarins and flavones induce ubiquitin independent proteasomal p53 degradation and thus inhibit p53 induced apoptosis ... Like dicoumarol, curcumin inhibited the activity of recombinant NQO1 in vitro, inhibited the activity of endogenous cellular NQO1 in vivo, and dissociated NQO1-WT p53 complexes
Asher et al., Cell cycle (Georgetown, Tex.) 2005 : Recent findings suggest that p53 also undergoes ubiquitin independent degradation by the 20S proteasomes and that this process is regulated by NAD(P)H quinone oxidoreductase 1 ( NQO1 ) together with NADH
Gong et al., Cancer Res 2007 (Liver Neoplasms, Experimental) : These results suggest that stress induced NQO1 and NQO2 transiently stabilize p53 , which leads to protection against adverse effects of stressors
Fagerholm et al., Nat Genet 2008 (Breast Neoplasms...) : NQO1 guards against oxidative stress and carcinogenesis and stabilizes p53
Begleiter et al., Leuk Res 2009 (Leukemia, Lymphocytic, Chronic, B-Cell) : NAD(P)H:quinoneoxidoreductase 1 ( NQO1 ) inhibits some cancers and increases p53 and apoptosis in cells